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. 2022 Dec 15;14(24):5495. doi: 10.3390/polym14245495

Table 1.

Nanoencapsulated essential oils and their biotechnological potential.

Essential Oil Nanoencapsulation Biotechnological Potential
Species Common Name Plant Part a Main Chemical
Compounds
Encapsulation Method Polymer
Carrier
Nanoproduct Obtained Biological
ACTIVITY
Application Industry
Piper nigrum Black
pepper
- β-caryophyllene (28%);
limonene (15%); sabinene (11.4%); β-pinene (11%)
Complex
Coacervation
Gelatin and sodium alginate Nanocapsules - - Food [13]
Aniba rosaeodora Rosewood Leaves linalool (81.46%); α-terpineol (7.4%); linalool oxide (1.56%) Ionic
gelidificaton-
emulsion
Chitosan Nanoemulsions Antifungal,
anti-
aflatoxigenic
Fruit coating Food [47]
Cymbopogon
citratus
Lemongrass Leaves citral (67.4%); neral (25.6%); geranial (41.8%); β-myrcene (18.1%) Nano-
Precipitation
poly(lactic acid)-PLA Nanocapsules Antifungal Fruit coating Food [48]
Pimpinella anisum Aniseed Fruits anethole (51.02%); estragole (24.75%); fenchone (13.22%) Ionic
gelidification-
emulsion
Chitosan Nanoemulsions Antioxidant, antifungal,
anti-
aflatoxigenic
Food
Preservative
Food [49]
Cymbopogon nardus Citronella grass - citral (62.73%);
geranyl acetate (9.53%);
geraniol (4.52%)
Ionic
gelidification-
emulsion
Chitosan Nanoemulsions Antioxidant, antifungal,
anti-
aflatoxigenic
Food
Preservative
Food [52]
Illicium verum Star anise Fruit anethole (89.12%);
estragole (4.85%)
Nano-
Precipitation
Chitosan Nanocapsules Antioxidant, antifungal,
anti-
aflatoxigenic
Food
Preservative
Food [53]
Thymus capitatus Conehead thyme Aerial parts carvacrol (76.1%); y-terpinene (6.7%); β-caryophyllene (2.7%) Nanoemulsion - Nanoemulsions Antibacterial Food
preservative
Food [54]
Kaempferia
galanga
Sand ginger Rhizomes ethyl-p-methoxycinnamate (59.4%); trans-methyl cinnamate (17.1%); pentadecane (6.9%) Nanoemulsion - Nanoemulsions Antifungal Food
preservative
Food [55]
Cinnamomum tamala Indian bay leaf Fruits linalool (82.64%);
caryophyllene oxide (3.1%); terpinen-4-ol (2.88%)
Ionic
Gelidification
Chitosan Nanoemulsions Antifungal, anti-
Aflatoxigenic
Food
preservative
Food [56]
Foeniculum vulgare Common fennel Fruits anethole (73.27%). fenchone (6.84%); D-limonene (4.39%) Nano-
Precipitation
Chitosan-
cinnamic acid
Nanogéis Antifungal, anti-
aflatoxigenic
Food
preservative
Food [57]
Coriandrum
sativum
Coriander Dried seeds linalool (65.18%);
geranyl acetate (12.06%); α-pinene (4.76%)
Ionic
gelidification-
emulsion
Chitosan Nanoemulsions Antioxidant, antifungal, anti-aflatoxigenic Food
preservative
Food [58]
Eugenia
caryophyllata
Cloves Ground aerial part eugenol (77.2%);
eugenyl acetate (8.31%); β-caryophyllene (7.19%)
Ionic
gelidification-
emulsion
Chitosan Nanocapsules Antifungal Food
preservative
Food [59]
Eugenia
caryophyllata
Cloves Flower buds eugenol (73.6%);
caryophyllene (9.67%);
oleic acid (2.03%)
Nano-
precipitation
Chitosan Nanogels Antioxidant, antifungal,
anti-
aflatoxigenic
- Food [61]
Citrus aurantium Seville
orange
Bark Nano-
precipitation
Chitosan Nanocapsules Antioxidant Food
preservative
Food [93]
Melaleuca cajuputi Cajuput Leaves α-pinene (49.24%); bornyl acetate (21.07%); camphor (11.70%) Ionic
gelidification
Chitosan Nanocapsules Antioxidant Food
preservative
Food [94]
Eryngium
campestre
Watling Street thistle Leaves and roots β-sesquiphellandrene (16.44%); isophytol (12.27%);
stigmasterol (10.11%)
Ionic
gelidification
Nanochitosan Nanocapsules Antioxidant Food
preservative
Food [95]
Myristica fragrans Mace Dried seeds myristicin (39.43%); methyleugenol (8.15%); safrole (6.26%) Nano-
precipitation
Chitosan-
cinnamic acid
Nanogels Antioxidant, antifungal, anti-
aflatoxigenic
Food
preservative
Food [96]
Petroselinum
crispum
Parsley Leaves carvacrol (48.45%);
D-limonene (20.80%); cuminaldehyde (15.78%)
Ionic
gelidification
Chitosan Nanoemulsions Antioxidant, antifungal, anti-
aflatoxigenic
Food
preservative
Food [98]
Ocimum basilicum Basil - eugenol (48.32%);
caryophyllene (26.26%);
methyl ester (5.78%)
Ionic
gelidification-
emulsion
Chitosan Nanocapsules Antibacterial, Antibiofilm Food
preservative
Food [99]
Thymus vulgaris Cymbopogon
citratus
Cinnamomum spp. Mentha × piperita Eugenia
caryophyllata
Thyme, lemongrass, Cinnamon, Peppermint, Cloves - Thyme: thymol (21.69%); p-cymene (21.31%); γ-terpinene (13.87%). Lemongrass: β-citral (31.33%); α-citral (14.65%). Cinnamon: eugenol (37.13%); caryophyllene (9.87%). Peppermint: menthol (29.4%); l-menthone (17.97%).
Cloves: eugenol (34.42%%);
eugenol acetate (24.53%%);
caryophyllene (21.30%%).
Nanoemulsion - Nanoemulsions Antifungal, mycotoxin
inhibitor
Food
preservative
Food [100]
Cinnamomum zeylanicum
Thymus vulgaris Syzygium
aromaticum
Cinnamon, Thyme, Cloves - - Oil in water emulsion Chitosan Nanoemulsions Antioxidant, antimicrobial Food
preservative
Food [101]
Origanum
compactum
Thymus vulgaris Melaleuca
alternifolia
Mentha × piperita
Compact oregano, Thyme,
Tea tree,
Peppermint
- Oregano: carvacrol (46.37%); thymol (13.70%); p-cymene (13.33%). Thyme: thymol (26.04%); p-cymene (26.36%); y-terpinene (16.69%). Tea tree: terpinen-4-ol (38.4%); γ-terpinene (22.6%).
Peppermint: menthol (33.38%); menthone (34.31%)
Nanoemulsion Chitosan Nanocapsules Antifungal Food storage Food [102]
Zingiber officinale Ginger - - Nanoemulsion Carnauba wax, hydroxypropylmethylcellulose Nanoemulsions - Food
preservative
Food [112]
Salvia rosmarinus Rosemary - - Nanoemulsion - Nanoemulsions - - Food [113]
Origanum
majorana
Sweet
marjorum
- terpinen-4-ol (28.92%); α-terpineol (16.75%);
linalool (11.07%)
Ionic
gelidification-
emulsion
Chitosan Nanocapsules Antioxidant, antifungal,
anti-
aflatoxigenic
- Food [114]
Myristica fragrans Nutmeg Seeds elemicin (27.08%); myristicin (21.29%); thujanol (18.55%) Ionic
gelidification
Chitosan Nanoemulsions Antifungal, anti-
Aflatoxigenic
Food
preservative
Food [115]
Pelargonium
graveolens
Rose-
scented geranium
Aerial parts citronelil (19.1%); menthone (16.7%); linalool (15.1%); isomenthone (12.2%) Oil in water emulsion Chitosan Nanogels Antifungal, anti
Aflatoxigenic
- Food [116]
Toddalia asiatica Orange climber Leaves caryophyllene oxide (24.4%); 1.3-hexadiene, 3-ethyl-2,5-dimethyl (24.08%); 1,4,7-cycloundecatriene,1,5,9,9- tetramethyl-Z,Z,Z (9.46%) Ionic
gelidification
Chitosan Nanocapsules Antifungal, anti-
Aflatoxigenic
- Food [117]
Bunium persicum Seeds cuminaldehyde (21.23%);
sabinene (14.66%);
γ-terpinene (12.49%)
Nanoemulsion Chitosan-
cinnamic acid
Nanogels Antifungal, anti-
aflatoxigenic, cytotoxic
Food
preservative
Food [118]
Myrtus communis Mentha pulegium Common myrtle,
Peppermint
Shoots - Nanoemulsion - Nanoemulsions Antimicrobial Food
preservative
Food [119]
Cinnamomum spp. Cinnamon - - Nanoemulsion - Nano-
emulsions
- - Food [120]
Satureja kermanica Savory Leaves thymol (46.54%); carvacrol (30.54%); γ-terpinene (6.58%) Nano-
precipitation
Chitosan-
cinnamic acid
Nanogels Antifungal - Food [121]
Cymbopogon
martinii
Palmarosa Leaves geraniol (19.06%);
geraniol (14.84%);
geranyl propionate (12.88%)
Nano-
precipitation
Chitosan Nanocapsules Antifungal Food
preservative
Food [122]
Syzygium sp. Cloves - - Nanoemulsion Gelatin, pullulan, inulin Nanoemulsions Antibacterial Food
preservative
Food [123]
Thymus vulgaris Thyme - thymol (43.63%); p-cymene (22.86%); bornyl acetate (8.70%) Nanoemulsion - Nanoemulsions Antimicrobial Food
preservative
Food [124]
Origanum vulgare Thymus capitatus Oregano Thyme Aerial parts thymol (43%); γ-terpinene (15%) and p-cymene (14%) Nano-
precipitation
Poly
(ε-caprolactone)
Nanocapsules Antibacterial - Pharmaceutical, food [71]
Origanum
glandulosum
Oregano Aerial parts carvacrol (26.29%);
γ-terpinene (23.43%);
thymol (19.52%)
High-speed homogenization, high-pressure homogenization Sodium alginate Nanocapsules Nanoemulsions Antioxidant, anticancer - Pharmaceutical, food [80]
Cinnamomum zeylanicum
Thymus vulgaris Schinus molle
Cinnamon, Thyme, Peruvian peppertree Leaves - Ionic
gelidification
Chitosan Nanocapsules Antimicrobial - Pharmaceutical, food [85]
Aniba canelilla Preciosa Leaves and branches 1-nitro-2-phenylethane (86.63%); methyleugenol (12.7%); benzaldehyde (0.663%) Nanoemulsion - Nanoemulsions Anti-
Chemotactic
Healing of infected wounds Pharmaceutical [46]
Eugenia
caryophyllata
Cloves Flower buttons eugenol (89.86%); β-caryophyllene (5.40%) Ionic
gelidification–
emulsion
Chitosan Nanoparticles Antioxidant, antibacterial Preservative, Medicine Pharmaceutical, cosmetic [60]
Thymus vulgaris Thyme - thymol (22.10%); p-cymene (21.31%); carvacrol (13.02%) High-pressure homogenization Nanoemulsions Antifungal Healing of infected wounds Pharmaceutical [75]
Homalomena
pineodora
- Leaves - Ionic
gelidification
Chitosan Nanocapsules Antimicrobial Healing of
diabetic ulcers
Pharmaceutical [76]
Morinda citrifolia Indian
mulberry
Seeds nordamnacanthal (22.34%); α-copaene (22.96%); α-morenone (20.45%) Nano-
precipitation
Chitosan Nanocapsules Anticancer - Pharmaceutical [78]
Citrus aurantium Citrus limon Citrus sinensis Seville
orange, Lemon,
Sweet
orange
- Seville orange: sabinene (15.6%); ɣ-terpinene (6.0%);
linalool (5.6%). Sweet orange: α-pinene (3.5%); sabinene (17%); trans-limonene oxide (3.1%). Lemon: trans-p-2,8-
menthadien-1-ol (5.0%);
cis-limonene oxide (2.6%); trans-limonene oxide (2.3%)
Ionic
gelidification
Chitosan Nanocapsules Anticancer - Pharmaceutical [79]
Origanum vulgare Thymus capitatos Oregano Thyme Aerial part - Ionic
gelidification
Chitosan Nanocapsules Antimicrobial Medicine Pharmaceutical [81]
Cinnamomum spp. Cinnamon Bark - Liposomes, lipid nanoparticles Sodium alginate Hybrid
composite nanoparticles
Antimicrobial Medicine Pharmaceutical [82]
Citrus aurantifolia, Citrus hystrix, Citrofortunella microcarpa Lime, Makrut lime Calamondin - - Spontaneous emulsification - Nanoemulsions Antibacterial Medicine Pharmaceutical [83]
Poiretia latifolia Erva de touro Leaves trans-dihydrocarvone (15.3–51.2%); carvone (12.3–39.0%); limonene (13.9–29.4%) Phase inversion Soy lecithin Lipossomes, Nanoemulsions Antifungal, anti-
Inflammatory, antioxidant
- Pharmaceutical [84]
Eugenia
caryophyllata
Cloves Aerial parts - High shear homogenization and ultrasound - Nanoemulsions Antimicrobial - Pharmaceutical [86]
Cymbopogon
commutatus
Lemongrass Whole plant geranial (38.6%);
neral (30.3%);
geranyl acetate (8.2%)
Ionic
gelidification-
emulsion
Chitosan Nanocapsules Antimicrobial - Pharmaceutical [87]
Mentha pulegium Pennyroyal - pulegone (72.18%); piperitenone (24.04%);
chrysanthenol (0.90%)
Hot melt homogenization Nanostructured lipid carriers (NLC) Nanogels Antimicrobial Healing of infected wounds Pharmaceutical, cosmetic [50]
Mentha × piperita Peppermint Leaves menthol (39.80%); menthone (19.55%); neomenthol (8.82%) Nanoemulsion Nanostructured lipid carriers (NLC) and xanthan gum Nanogels Antimicrobial Healing of infected wounds Pharmaceutical, cosmetic [74]
Cynometra
cauliflora
Nam Nam Leaves, branches, fruits - Ionic
Gelidification–
emulsion
Chitosan Nanocapsules Antimicrobial, antioxidant, cytotoxic Pharmaceutical, cosmetic [77]
Cedrus deodara Cedar Sawdust α-cedarene (32.72%); β-cedarene (12.26%);
thujopsene (24.03%)
Nanoemulsion Modified starch Nanoemulsions Antioxidant, antibacterial Preservative, Medicine Pharmaceutical, cosmetic [89]
Thymus vulgaris Melissa officinalis Thyme,
Lemon balm, Black caraway
- - Phase inversion Sunflower oil Nanoemulsions Antioxidant, antibacterial - Pharmaceutical, cosmetic [90]
Mentha × piperita Camellia sinensis Peppermint, Green tea - - Nano-
precipitation
Chitosan Nanocapsules Antimicrobial, antioxidant - Pharmaceutical, cosmetic [91]
Syzygium
aromaticum
Cloves Flower buds eugenol (71.92%); β-caryophyllene (22.80%); chavibetol acetate (2.89%) Intercalation Bentonite clay and polyvinylpyrrolidone (PVP) Nano-
composites
Cytotoxic,
Larvicide
- Pharmaceutical, environmental [51]
Ocimum basilicum Basil Leaves trans-β-guaiene (16.89%); α-cadinol (15.66%);
phytol (11.68%)
Nanoemulsion - Nanoemulsions Antioxidant, antibacterial, larvicide - Pharmaceutical, environmental [105]
Satureja hortensis Summer savory Aerial parts carvacrol (35.2%); γ-terpinene (17.6%); thymol (12.1%) Ionic
gelidification
Chitosan Nanocapsules Acaricide - Environmental [107]
Cymbopogon
nardus
Citronella grass - - Ionic
gelidification
Chitosan and
cellulose
Nanocapsules Insecticide Pest control Environmental [103]
Mentha × piperita Peppermint Dried leaves l-menthone (32.27%);
menthol (23.47%); α-phellandrene (7.71%)
Ionic
Gelidification–
emulsion
Chitosan Nanocapsules Insecticide Pest control Environmental [104]
Siparuna
guianensis
Negramina Whole plant - Nanoemulsion Chitosan Nanocapsules Larvicide Pest control Environmental [106]
Cannabis sativa Marijuana Aerial parts (E)-caryophyllene (23.1%); α-pinene (15.8%);
myrcene (14.5%)
Nano-
precipitation
Alfalfa protein Nanocapsules Antioxidant - Cosmetic, food [92]
Cymbopogon
densiflorus
Lemongrass Leaves trans-p-mentha-2,8-dien-1-ol (13.13%);
cis-p-mentha-2,8- dien-1-ol (17.29%);
trans-p-mentha-1(7),8-dien-2-ol (18.99%)
Phase inversion - Nanoemulsions Antioxidant - Cosmetic [125]

a Part of the plant used in the extraction of the essential oil.