Table 3.

Risk Factors for non-adherence to antidepressants among the Castile and Leon (Spain) population during 2021.

	AOR (95% CI)	p
Sociodemographic characteristics
Age	0.94 (0.94–0.94)	0.001
Gender (Female)	0.91 (0.88–0.94)	0.001
Urbanicity	1.31 (1.27–1.36)	0.001
Institutionalized	0.32 (0.27–0.38)	0.001
Health related characteristics
Polypharmacy (≥5)	0.78 (0.76–0.81)	0.001
Multiple prescribers (≥3)	0.97 (0.93–1.01)	0.322
Antidepressants class
SSRIs	1 (0.96–1.04)	0.99
Other antidepressants	0.95 (0.91–1)	0.23
TCAs	1.48 (1.39–1.57)	0.001
Mental health diagnostics
Depression and/or anxiety	0.77 (0.7–0.84)	0.001
Pain (different etiologies)	1.3 (1.23–1.38)	0.001
Other psychiatric diagnosis	0.67 (0.63–0.72)	0.001

Abbreviations: SD, standard deviation; CI, confidence interval; SSRIs, Selective Serotonin Reuptake Inhibitors; TCAs, Tricyclic Antidepressants.