Table 2.

Treatment regimens for latent TB infection in pregnancy.

Regimen	Dosing	Comment
6H or 9H Isoniazid * daily for 6 or 9 months	Isoniazid 5 mg/kg (300 mg maximum)	CDC/WHO: preferred for pregnant PWHIV
36H Isoniazid * daily for 36 months	Isoniazid 5 mg/kg (300 mg maximum)	WHO: preferred in settings of high TB transmission including pregnant PWHIV
3HR Isoniazid * AND Rifampin daily for 3 months	Isoniazid 5 mg/kg (300 mg maximum) AND Rifampin 10 mg/kg (600 mg maximum)
4R Rifampin daily for 4 months	Rifampin 10 mg/kg (600 mg maximum)
3HP¶ Isoniazid * AND Rifapentine weekly for 3 months	Not currently recommended in pregnancy (some pregnancy safety data)
1HP¶ Isoniazid * AND Rifapentine daily for 1 month	Not currently recommended in pregnancy (no data in pregnancy, trials planned)

Abbreviations: CDC = US Centers for Disease Control and Prevention; WHO = World Health Organization; PWHIV = people with HIV; ^* Isoniazid containing regimens should be administered with pyridoxine (B6) 25 to 50 mg daily to reduce risk of peripheral neuropathy; ^¶ Data on safety of rifapentine in pregnancy are limited; therefore, 3HP and 1HP are not currently recommended in people who are pregnant or expecting to become pregnant during the treatment period.