Table 3.

Multivariate analysis of plasma HIV RNA during and post-intervention period.

Models	Variables	Coefficient	95% CI		P-value
Model 1. Intervention period (week 4–16)	Intercept	2.013	0.810	3.216	0.001
	log plasma HIV RNA at week 4	0.672	0.385	0.959	<0.001
	Ingestible sensor (ref: UC)	0.851	−0.912	2.614	0.341
	Average adherence at weeks 4, 8, 12,16	−1.512	−2.740	−0.284	0.016
	IS∗Adherence	−0.882	−2.847	1.082	0.375
Model 2. Post-intervention period (week 16–28)	Intercept	2.964	1.418	4.510	<0.001
	Log plasma HIV RNA at week 16	0.532	0.256	0.807	<0.001
	Ingestible sensor (ref: UC)	−0.734	−3.180	1.713	0.553
	Average adherence at weeks 16, 20, 24, 28	−2.073	−3.587	−0.560	0.008
	IS∗Adherence	0.670	−2.013	3.352	0.621
Model 3. Longitudinal mixed-effects (week 4–28)	Intercept	1.722	1.231	2.219	<0.001
	Week	−0.003	−0.030	0.023	0.799
	Week2	0.0003	−0.001	0.001	0.454
	Ingestible sensor (ref: UC)	−0.726	−1.365	−0.081	0.028
	Weekly adherence	−0.423	−0.900	0.048	0.082
	IS∗Adherence	0.723	0.024	1.413	0.042
	Baseline log plasma HIV RNA	0.274	0.188	0.360	<0.001

IS, ingestible sensor; UC, usual care.