Table 1.
Details of the evaluated ten commercial immunoassays.
| Product | Manufacturer | Isotype antibodies | Targeted antigens | Cut-off value | Platform |
|---|---|---|---|---|---|
| Abbott ARCHITECT SARS-CoV-2 IgG | Abbott | IgG | Nucleocapsid | 1.4 S/C | Chemiluminescent microparticle immunoassay (CMIA) |
| FRENDTM COVID-19 | NanoEntek, Inc. | IgG | Nucleocapsid | 1 COI | Fluoroimmunoassay (FIA) |
| Elecsys Anti-SARS-CoV-2 | Roche | Total antibodies | Nucleocapsid | 1 COI | Electro-Chemiluminescence Immunoassay (ECLIA) |
| MAGLUMI 2019-nCoV IgG | SNIBE Co., Ltd | IgG | Nucleocapsid and Spike | 1 AU/mL | Chemiluminescence immunoassay (CLIA) |
| Access SARS-CoV-2 IgG | Beckman Coulter, Inc. | IgG | Spike | 1 S/CO | Chemiluminescence immunoassay (CLIA) |
| SARS-CoV-2 S-RBD IgG | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | IgG | Spike | 6 U/mL | Chemiluminescence immunoassay (CLIA) |
| SARS-CoV-2 Total antibodies | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Total antibodies | Spike | 10 U/mL | Chemiluminescence immunoassay (CLIA) |
| ADVIA Centaur SARS-CoV-2 Total (COV2T) | Siemens Healthcare Diagnostics | Total antibodies | Spike | 1 index | Chemiluminescence immunoassay (CLIA) |
| Anti-SARS-CoV-2 Neutralizing Antibody ELISA Kit | Nanjing Vazyme Medical Technology Co., Ltd | Neutralizing antibodies (all isotypes) | Spike | 20 % inhibition rate | surrogate virus neutralisation test (sVNT) ELISA |
| cPass SARS-CoV-2 Neutralization Antibody Detection Kit | GenScript USA Inc. | Neutralizing antibodies (all isotypes) | Spike | 20% inhibition rate | surrogate virus neutralisation test (sVNT) ELISA |
Note: AU (arbitrary unit), U (unit), COI (cut-off index), S/C (signal to cut-off), S/CO (signal to cut-off).