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. 2022 Nov 26;14(12):2614. doi: 10.3390/pharmaceutics14122614

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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In vivo distribution of PL in Sprague Dawley rats. (A) Relative fluorescence intensities of plasma samples derived from rats treated with DiR or DiR@PL, detected by a microplate reader. (B) Relative fluorescence intensities of plasma samples derived from rats treated with DiR or DiR@PL, detected by an image system. (C) Representative fluorescence images of plasma samples derived from rats treated with DiR or DiR@PL. (D) Typical ex vivo imaging of major organs at 8 h after injection. (E) Quantified distribution in major organs. Data were presented as the means ± SDs (n = 4).