Table 1.

List of the main human CaMs gene polymorphisms. CaM polymorphisms are associated with a spectrum of arrhythmic phenotypes. Adapted from Kotta et al. [61].

Gene	Nucleotide Change	Amino Acid Change	Associated Phenotype	Refs.
CALM1	c.389A>G	p.D130G	LQTS	[59,61]
CALM1	c.426C>G	p.F142L	LQTS	[59,61]
CALM1	c.161A>T	p.N54I	CPVT	[61,66]
CALM1	c.293A>G	p.N98S	LQTS, CPVT	[61,66]
CALM1	c.268T>C	p.F90L	IVF, SUD	[67,69]
CALM1	c.395A>T	p.D132V	LQTS	[64]
CALM2	c.293A>G	p.N98S	LQTS, SUD	[61,62,68]
CALM2	c.287A>T	p.D96V	LQTS	[59,61]
CALM2	c.293A>T	p.N98I	LQTS	[61,62]
CALM2	c.400G>C	p.D134H	LQTS	[38,39]
CALM2	c.389A>G	p.D130G	LQTS	[61]
CALM2	c.396T>G	p.D132E	LQTS, CPVT	[61,62]
CALM2	c.394G>C	p.D132H	LQTS	[64]
CALM2	c.407A>C	p.Q136P	LQTS, CPVT	[62]
CALM3	c.389A>G	p.D130G	LQTS	[61,63]
CALM3	c.308C>T	p.A103V	CPVT	[61]
CALM3	c.286G>C	p.D96H	LQTS	[61,65]
CALM3	c.426T>G	p.F142L	LQTS	[61,65]