PD-1 |
programmed cell death protein-1 |
PD-L1/2 |
programmed death-ligand 1/2 |
CTLA-4 |
cytotoxic T-lymphocyte-associated protein 4 |
TIM-3 |
T-cell immunoglobulin and mucin domain-3 |
LAG-3 |
lymphocyte activation gene-3 |
TIGIT |
T cell immunoreceptor with immunoglobulin and ITIM domains |
PTMs |
Post-translational Modifications |
GPI |
glycosylphosphatidylinositol |
ER |
endoplasmic reticulum |
OST |
oligosaccharyltransferase |
ERAD |
ER-associated degradation |
ERLAD |
ER-to-lysosomes-associated degradation |
UDP-GlcNAc |
uridine diphosphate N-acetylglucosamine |
HBP |
hexosamine biosynthetic pathway |
OGT |
O-GlcNAc transferase |
OGA |
O-GlcNAcase |
TCR |
T-cell-receptor |
MHC |
major histocompatibility complex |
APCs |
antigen-presenting cells |
FUT8 |
Fucosyltransferase 8 |
B3GNT3 |
β-1,3-N-acetylglucosaminyl-transferase |
CSCs |
Cancer stem cells |
EMT |
epithelial-mesenchymal transition |
GSK3β |
glycogen synthase kinase 3β |
TNBC |
Triple-Negative Breast Cancer |
AMPK |
Adenosine 5′-monophosphate (AMP)-activated protein kinase |
CTL |
cytotoxic T lymphocyte |
IHC |
immunohistochemical |
FFPE |
Formalin-fixed paraffin-embedding |
PNGase |
F peptide-N-glycosidase F; |
HNSCC |
head and neck squamous cell carcinoma |
EGF/EGFR |
Epidermal Growth Factor/Epidermal Growth Factor Receptor |
ICOS/ICOSL |
inducible co-stimulator/ inducible co-stimulator ligand |
NK cells |
natural killer cells |
NCRs |
natural cytotoxicity receptors |
LSECtin |
liver sinusoidal endothelial cell lectin |
TIGIT |
T cell immunoreceptor with immunoglobulin and ITIM domains |
CRD |
cysteine-rich domains |
Gal-9 |
galectin-9 |
Siglec |
Sialic acid-binding immunoglobulin-like lectin |
IAP |
integrin-associated protein |
SIRPα |
signal regulatory protein α |
TAMs |
tumor-associated macrophages |
NKG2D |
natural killer group 2D |
MICA/B |
MHC class I polypeptide-related sequence A/B |
SLAM |
Signaling Lymphocyte Activation Molecule |
DC |
dendritic cells |
SRPK2 |
serine/arginine-rich protein kinase 2 |
PGK1 |
phosphoglycerate kinase 1 |
TCA |
tricarboxylic acid |
2F-Fuc |
2-fluoro-L-Fucose |
2-DG |
2-deoxy-glucose |
PARP |
Poly ADP-ribose polymerase |
Fab |
fragment antigen binding |
Fc |
fragment crystallizable |
ADCC |
Antibody-dependent cell-mediated cytotoxicity |