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. 2022 Dec 16;14(12):2825. doi: 10.3390/pharmaceutics14122825

Table 2.

Detailed composition of the transdermal microemulsions developed by the works included in this review. Excipient and drug quantities and units are shown as reported in the respective articles (w/w% for excipients, and mg/mL for drugs). For the excipients, usually the brand name was used (when available).

Composition Transdermal Brexanolone Microemulsions [37]
o/w w/o
Oil Oleic acid 7.00% w/w 10.00% w/w
Hydrophobic surfactant Plurol® Oleique CC 497 1 7.14% w/w 11.43% w/w
Hydrophilic surfactant Labrasol® 2 42.86% w/w 68.57% w/w
Cosolvent Transcutol® P 3 17.20% w/w 4.00% w/w
Water - 25.80% w/w 6.00% w/w
Drug Brexanolone 10 mg/mL 19 mg/mL

1 polyglyceryl-3 dioleate; 2 polyethylene glycol-8 caprylic/capric glycerides; 3 diethylene glycol monoethyl ether.