Table 2.
Composition | Transdermal Brexanolone Microemulsions [37] | ||
---|---|---|---|
o/w | w/o | ||
Oil | Oleic acid | 7.00% w/w | 10.00% w/w |
Hydrophobic surfactant | Plurol® Oleique CC 497 1 | 7.14% w/w | 11.43% w/w |
Hydrophilic surfactant | Labrasol® 2 | 42.86% w/w | 68.57% w/w |
Cosolvent | Transcutol® P 3 | 17.20% w/w | 4.00% w/w |
Water | - | 25.80% w/w | 6.00% w/w |
Drug | Brexanolone | 10 mg/mL | 19 mg/mL |
1 polyglyceryl-3 dioleate; 2 polyethylene glycol-8 caprylic/capric glycerides; 3 diethylene glycol monoethyl ether.