Table 1.

Molecular mechanisms and intracellular modifications underlying ischemic cardiomyopathy (ICM).

Molecular Mechanisms and Intracellular Modifications Underlying Ischemic Cardiomyopathy	Studies
- Increase of cytokines (IL-6; TNFα), microRNA, plasminogen activator inhibitor-1 (PAI-1)	[38,41,42]
- Impairment of autophagy	[44]
- The release of IFN-γ, perforin and granzyme by senescent T cells	[45,46,47]
- Reduction of NAD+ levels	[48]
- Telomere shortening and dysfunction	[49,50]