Table 2.
Venom proteome of N. nivea according to protein families and relative abundance.
| Protein Family | Protein Name | Accession a | Species | R.A. (%) b |
|---|---|---|---|---|
| Three-finger toxins (3FTX) | 84.62 | |||
| Short neurotoxin (SNTX) | 3.61 | |||
| Short neurotoxin 2 | P01422 | Naja annulifera | 1.58 | |
| Short neurotoxin 4 | P01421 | Naja annulifera | 2.03 | |
| Long neurotoxin (LNTX) | 3.78 | |||
| Long neurotoxin 1 | P01390 | Naja nivea | 3.78 | |
| Weak neurotoxin (WTX) | 1.58 | |||
| Weak toxin CM-13b | P01399 | Naja annulifera | 0.45 | |
| Weak toxin S4C11 | P01400 | Naja melanoleuca | 0.04 | |
| Weak toxin CM-11 | P01401 | Naja haje haje | 0.17 | |
| Weak toxin CM-10 | P25680 | Naja nivea | 0.91 | |
| Cytotoxin/cardiotoxin (CTX) | 75.65 | |||
| Cytotoxin 10 | P01453 | Naja annulifera | 4.53 | |
| Cytotoxin 1 | P01456 | Naja nivea | 29.43 | |
| Cytotoxin 3 | P01458 | Naja nivea | 10.36 | |
| Cytotoxin 3 | P01459 | Naja annulifera | 0.21 | |
| Cytotoxin 8 | P01460 | Naja annulifera | 13.37 | |
| Cytotoxin 2 | P01462 | Naja annulifera | 5.15 | |
| Cytotoxin 2 | P01463 | Naja nivea | 2.65 | |
| Cytotoxin 7 | P01466 | Naja annulifera | 7.95 | |
| Cytotoxin 1 | P01468 | Naja pallida | 0.20 | |
| Cytotoxin homolog | P14541 | Naja kaouthia | 1.79 | |
| Cytotoxin 11 | P62394 | Naja haje haje | <0.01 | |
| Snake venom metalloproteinase (SVMP) | 6.79 | |||
| microlepidotease-1 | B5KFV6 | Oxyuranus microlepidotus | 0.15 | |
| Zinc metalloproteinase-disintegrin cobrin | CL115.Contig9_NkT | Naja kaouthia | 0.01 | |
| Zinc metalloproteinase-disintegrin atragin | CL2051.Contig1_NkM | Naja kaouthia | 0.33 | |
| Scutellatease-1 | CL2215.Contig1_HsM | Hydrophis schistosus | 0.30 | |
| Zinc metalloproteinase-disintegrin cobrin | CL2966.Contig3_NnSL | Naja naja | 2.37 | |
| Zinc metalloproteinase-disintegrin-like atragin | CL444.Contig1_NsM | Naja sumatrana | 0.64 | |
| Zinc metalloproteinase-disintegrin atragin | CL626.Contig4_NsM2 | Naja sumatrana | 0.10 | |
| Zinc metalloproteinase-disintegrin cobrin | CL7366.Contig1_OhM | Ophiophagus hannah | 0.03 | |
| Zinc metalloproteinase-disintegrin-like atragin | D3TTC2 | Naja atra | 0.21 | |
| Zinc metalloproteinase-disintegrin-like atrase-A | D5LMJ3 | Naja atra | 1.49 | |
| Hemorrhagic metalloproteinase-disintegrin-like kaouthiagin | P82942 | Naja kaouthia | 0.21 | |
| Snake venom metalloproteinase-disintegrin-like mocarhagin | Q10749 | Naja mossambica | 0.24 | |
| Zinc metalloproteinase-disintegrin-like VLAIP-A | Q4VM08 | Macrovipera lebetina | 0.11 | |
| SVMP-Aca-4 | R4G2D3 | Acanthophis wellsi | 0.04 | |
| SVMP-Hop-45 | R4G2Y9 | Hoplocephalus bungaroides | 0.38 | |
| Metalloproteinase (Type III) 1 | U3EPC7 | Micrurus fulvius | 0.15 | |
| Zinc metalloproteinase mocarhagin | unigene25077_NnSL | Naja naja | 0.04 | |
| Cysteine-rich secretory protein (CRISP) | 3.56 | |||
| Natrin-1 | CL85.Contig1_NnSL | Naja naja | 1.51 | |
| Cysteine-rich venom protein ophanin | Q7ZT98 | Ophiophagus hannah | 0.04 | |
| Cysteine-rich venom protein natrin-1 | Q7T1K6 | Naja atra | 1.41 | |
| Cysteine-rich venom protein natrin-2 | Q7ZZN8 | Naja atra | 0.44 | |
| Cysteine-rich venom protein latisemin | Q8JI38 | Laticauda semifasciata | 0.16 | |
| Kunitz-type serine protease inhibitor (KSPI) | 1.24 | |||
| Kunitz-type serine protease inhibitor 2 | P00986 | Naja nivea | 1.24 | |
| Nerve growth factor (NGF) | 1.22 | |||
| Venom nerve growth factor 2 | CL429.Contig1_NnSL | Naja naja | 1.12 | |
| Venom nerve growth factor 2 | Q5YF89 | Naja sputatrix | 0.10 | |
| Phosphodiesterase (PDE) | 1.00 | |||
| Phosphodiesterase | A0A194ARD7 | Micrurus tener | 0.30 | |
| Phosphodiesterase 1 | CL4383.Contig2_OhM | Ophiophagus hannah | 0.54 | |
| Phosphodiesterase 1 | unigene5869_NsM | Naja sumatrana | 0.15 | |
| 5′-nucleotidase (5′-NUC) | 0.75 | |||
| Snake venom 5′-nucleotidase | CL3600.Contig1_NsM2 | Naja sumatrana | 0.39 | |
| Snake venom 5′-nucleotidase | CL4180.Contig1_OhM | Ophiophagus hannah | 0.36 | |
| L-amino acid oxidase (LAAO) | 0.48 | |||
| L-amino-acid oxidase | CL4047.Contig1_NsM2 | Naja sumatrana | 0.07 | |
| L-amino-acid oxidase | A8QL58 | Naja atra | 0.06 | |
| L-amino acid oxidase | A8QL51 | Bungarus multicinctus | 0.15 | |
| L-amino-acid oxidase-like | A0A6J1W8Y3 | Notechis scutatus | 0.20 | |
| Cobra venom factor (CVF) | 0.20 | |||
| Cobra venom factor | unigene370_NsM2 | Naja sumatrana | 0.03 | |
| Cobra venom factor | CL4560.Contig1_NsM | Naja sumatrana | 0.04 | |
| Cobra venom factor | Q91132 | Naja kaouthia | 0.13 | |
| Acetylcholinesterase (AChE) | 0.10 | |||
| Acetylcholinesterase NS2 | CL4231.Contig1_NsM | Naja sumatrana | 0.05 | |
| Acetylcholinesterase | unigene16279_OhM | Ophiophagus hannah | 0.05 | |
| Vespryn (VES) | 0.04 | |||
| Thaicobrin | P82885 | Naja kaouthia | 0.04 | |
a Accession codes with the suffix “_xxxx” were proteins identified based on tryptic peptides matched to sequences from an in-house transcript database. b RA: Relative abundance is represented as the percentage of total venom proteins.