Figure 4.

Comparison of the Blp and LasA structures. (a) Superimposition of the structures of the LasA (blue) and Blp (grey) active sites with a substrate analogue. Interactions of LasA and Blp with a substrate analogue were modelled based on the structure of LytM catalytic domain with the phosphinic derivative of tetraglycine (PDB ID 4ZYB). The grey sphere indicates the zinc ion. The amino acid residues for LasA and Blp, which may affect the geometry of the active−site groove, are given, respectively, in blue and grey. (b) The surface of Blp with superimposed residues of LasA, presented in (a), and the substrate analogue, are shown.