FIGURE 1.

Flowchart of NPS‐guided multimodal fusion and prediction analysis. (a) NPS total score was set as the reference to guide the four‐way MRI fusion. (b) Correlation analysis and linear regression were performed to estimate the associations between the identified multimodal pattern and baseline cognitive performance across groups and longitudinal cognitive scores in the subgroup, respectively. (c) The same fusion with reference method was performed by using four subsyndrome scores as the reference individually, to guide the four‐way MRI fusion to further identify the common and unique multimodal attributes. ALFF, amplitude of low frequency fluctuations; GMV, gray matter volume; IC, independent components; ICA, independent component analysis; MCCAR, multisite canonical correlation analysis with reference; NPS, neuropsychiatric symptoms; SUVR, standard uptake value ratios