Table 1.

EMT transcription factors and their role in EMT mechanisms to promote CLM development.

EMT-TFs	Members of TF Family	Mechanisms in CLM-Related EMT	References
Snail	Snail1, Snail2 (SLUG genes)	▪ E-cadherin downregulation ▪ Vimentin, N-cadherin, and fibronectin mesenchymal genes upregulation	[60,61]
Zeb	Zeb1, Zeb2	▪ E-cadherin downregulation ▪ LAMC2 mesenchymal gene upregulation ▪ Severe alterations in the expression pattern of chromatin-modifying enzymes	[67,68,69]
Twist	Twist1, Twist2	▪ N-cadherin and fibronectin upregulation ▪ Loss of E-cadherin-mediated cell–cell adhesion ▪ Tumor migration and invasion ▪ Possible induction of chemoresistance to the drug oxaliplatin	[70,71,72]