Screening the reaction parameters for the nitration of phenol under the catalysis of PMA@MIL-53 (Fe).
| |||||
|---|---|---|---|---|---|
| Entry | Catalyst | Time (min) | Yielda,b,c (%) | ||
| Total | Ortho | Para | |||
| 1 | — | 5 | NR | — | — |
| 2 | MIL-53 (Fe) | 5 | NR | — | — |
| 3 | PMA (10 wt%)@MIL-53 (Fe) | 5 | 29.5 | 16.41 | 13.09 |
| 4 | PMA (10 wt%)@MIL-53 (Fe) | 10 | 75.13 | 41.11 | 34.02 |
| 5 | PMA (10 wt%)@MIL-53 (Fe) | 15 | 95.62 | 51.91 | 43.71 |
| 6 | PMA (20 wt%)@MIL-53 (Fe) | 5 | 38.54 | 20.71 | 17.83 |
| 7 | PMA (20 wt%)@MIL-53 (Fe) | 10 | 76.94 | 44.02 | 32.92 |
| 8 | PMA (20 wt%)@MIL-53 (Fe) | 15 | 99.99 | 54.98 | 45.01 |
| 9 | PMA (20 wt%)@MIL-53 (Fe) | 15 | NRc | — | — |
a
GC yields.
b
Conditions: phenol (4 mL), nitric acid (4 mL) PMA@MIL-53 (Fe) (100 mg) in acetone (10 mL) at room temperature under ultrasound irradiation.
c
The reaction in the absence of HNO3.