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. 2022 Dec 19;27(24):9063. doi: 10.3390/molecules27249063
ALT alanine aminotransferase
ULN upper limits of normal
CYPs cytochrome P450 family
7-HC 7-hydroxycoumarin
7-HCG 7-hydroxycoumarin-glucuronide
CE 3,4-epoxycoumarin
o-HPA o-hydroxyphenylacetaldehyde
o-HPAA o-hydroxyphenylacetic acid
GSH glutathione
SGPT serum glutamic pyruvic transaminase
AST aspartate transaminase
gamma-GT/GGT gamma-glutamyl transpeptidase
TDI Tolerable Daily Intake
EFSA European Food Safety Authority
NOAEL No Observed Adverse Effect Level
BfR German Federal Institute for Risk Assessment
ALDH aldehyde dehydrogenase
NAMs new approach methodologies system
NGRA Next Generation Risk Assessment