Table 2.
Primary, secondary, and exploratory outcomes
| Outcomes | T-piece SBT (n = 54) |
High-flow oxygen SBT (n = 54) |
Risk difference (95% CI) |
p value |
|---|---|---|---|---|
| Primary outcome | ||||
| Weaning failure on Day 2, no. (%)a | 5 (9.3) | 3 (5.6) | 3.7 (− 6.1–13.6) | 0.713 |
| Secondary and exploratory outcomes | ||||
| Weaning failure on day 7, no (%)b | 13 (24.1) | 7 (13.0) | 11.1 (− 3.4–25.6) | 0.215 |
| Successful SBT within 72 h, no. (%) | 53 (98.1) | 54 (100) | − 1.9 (− 5.5–1.7) | > 0.999 |
| Extubation after first SBT, no. (%) | 51 (94.4) | 53 (98.1) | − 3.7 (− 10.8–3.4) | 0.610 |
| Reintubation within 48 h, n/total (%)c | 4/53 (7.5) | 2/53 (3.8) | 3.7 (− 5.0–12.5) | 0.674 |
| Reintubation within 7 d, n/total (%)c | 12/53 (22.6) | 6/53 (11.3) | 11.3 (− 2.8–25.4) | 0.196 |
| Apply NIV within 48 h after extubation, no. (%)c | 11/53 (20.7) | 13/53 (24.5) | − 3.8 (− 19.7–12.1) | 0.816 |
| Apply HFNC within 48 h after extubation, no. (%)c | 40/53 (75.5) | 42/53 (79.2) | − 3.7 (− 19.7–12.1) | 0.816 |
| ICU length of stay, d | 3 (1–7) | 2 (1–5) | 0.107 | |
| Hospital length of stay, d | 22 (12–44) | 25 (16–46) | 0.435 | |
| ICU mortality, no. (%) | 3 (5.6) | 3 (5.6) | 0.0 (− 8.6–8.6) | > 0.999 |
| Hospital mortality, no. (%) | 21 (38.9) | 19 (35.2) | 3.7 (− 14.5–21.9) | 0.842 |
HFNC High-flow nasal cannula, ICU Intensive care unit, NIV Noninvasive ventilation, SBT Spontaneous breathing trial
aDefined as either the failure of SBT within 72 h after starting the first SBT or the need for reintubation or death within 48 h following extubation
bDefined as either the failure of SBT within 72 h after starting the first SBT or the need for reintubation or death within 7 days following extubation
cAmong patients extubated after successful SBT within 72 h