Table 3.

Results of the gene set enrichment analysis for Bombus waltoni.

4500 m vs. 4000 m		5000 m vs. 4000 m
GO term	NES	GO term	NES
Extracellular region	−2.64	Regulation of chemotaxis	−3.12
Motile cilium	−2.61	Regulation of locomotion	−2.55
Structural constituent of cuticle	−2.50	Response to herbicide	−2.48
Odorant binding	−2.45	snoRNA binding	−2.36
Cilium	−2.42	rRNA modification	−2.30
1-acyl-2-lysophosphatidylserine acylhydrolase activity	−2.32	Electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	−2.37
Fatty-acyl-CoA reductase (alcohol-forming) activity	−2.29	Odorant binding	−2.11
Alcohol-forming fatty acyl-CoA reductase activity	−2.28	Regulation of response to external stimulus	−2.07
Phospholipase A1 activity	−2.28	Cytosolic ribosome	−1.96
Phosphatidylserine 1-acylhydrolase activity	−2.26	Demethylation	2.08
Chitin binding	−2.25	Olfactory receptor activity	−1.90
Signaling receptor activity	−2.25
Cell junction	−2.23
Cell projection	−2.23
Dynein complex	−2.22
Transmembrane signaling receptor activity	−2.18
Triglyceride lipase activity	−2.16
Plasma membrane bounded cell projection	−2.15
Cyclic-nucleotide phosphodiesterase activity	−2.06
Wnt signaling pathway	−2.06

The samples from the lower altitude were set as the control group in each analysis. The enriched Gene ontology (GO) terms with the top 20 largest absolute normalized enrichment score (NES) are shown here. Columns for 5000 m vs. 4500 m are absent, as no significant GO terms were found in this comparison. The meanings of the NES values are same as in Table 2. The terms shared in the two comparisons are in bold. The genes that contributed significantly to these terms are in Table S1.