Table 1.

Type of effective MiRNAs in POF

MiRNA	Function in POF	Refs
1. Mir23a	Both TRERNA1 and miR-23a were downregulated in POF	[92–97]
2. miR-146b-5p	Increased DLEU1 expression and decreased miR-146b-5p expression were observed in POF. DLEU1 promoted cell apoptosis and reduced the inhibitory effects of miR-146b-5p on cell apoptosis	[93, 98–100]
3. MiR-144-5p	exosomal miR-144-5p in BMSCs was able to directly target PTEN, a protein involved in the apoptosis of CTX-damaged GCs. PTEN has been shown to negatively regulate the PI3K/AKT pathway and induce apoptosis or cell cycle arrest at the G1 phase	[101–105]
4. miR-15b	overexpression of miR-15b induces POI by silencing the endogenous α-Klotho mRNA and stimulating the activity of the downstream transforming growth factor β1 (TGFβ1)/SMAD pathway	[106–108]
5. miR-146a	miR-146a contributes to the apoptosis of ovarian granulosa cells via the caspase cascade by directly targeting IRAK1 and TRAF6	[109–113]