Table 2.
Pharmacokinetic parameters of CLX in the solvent control and SM groups after a single oral dose of 30 mg/kg CLX.
| PK Parameters | Control Group | Silymarin Group |
|---|---|---|
| t1/2 (h) | 1.68 ± 0.73 | 3.92 ± 1.25 ** |
| tmax (h) | 0.75 ± 0.67 | 0.58 ± 0.30 |
| Cmax (ng/mL) | 16,600.00 ± 4681.45 | 23,116.67 ± 6467.89 |
| Vd (mL/kg) | 1871.34 ± 1107.17 | 1566.26 ± 674.78 |
| CL (mL/h/kg) | 745.77 ± 266.34 | 272.12 ± 41.99 ** |
| MRT (h) | 2.56 ± 0.83 | 5.94 ± 1.63 ** |
| AUC0-t (h × ng/mL) | 42,888.64 ± 14,453.20 | 91,847.01 ± 16,565.67 *** |
| AUC0-∞ (h × ng/mL) | 44,469.95 ± 14,578.90 | 11,2307.50 ± 16,077.58 *** |
** p < 0.01, *** p < 0.001 compared with the solvent control group.