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. 2022 Dec 19;23(24):16199. doi: 10.3390/ijms232416199

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Study design and workflow: examining the relationship of cognitive traits and AD with GIT disorders. AD: Alzheimer’s disease, IBS: irritable bowel syndrome, PUD: peptic ulcer disease, GERD: gastroesophageal reflux disease, IBD: inflammatory bowel disease, GD: gastritis-duodenitis, Divertic: diverticulosis, AgeFullEdu: age completed full-time education, FI-ChainedArithm: fluid intelligence-chained arithmetic, FI-CondArithm: fluid intelligence-conditional arithmetic, FI-famRelatCal: fluid intelligence-family relationship calculation, FI-WordInterp: fluid intelligence-word interpolation, CognPerf: cognitive performance, Educ-qual: educational qualification, EduAttmt: educational attainment. GWAS: genome-wide association studies, GIT: gastrointestinal tract, LDSC: linkage disequilibrium score regression, LAVA: local analysis of [co]variant association, MAGMA: multi-marker analysis of genomic annotation, 2SMR: two-sample Mendelian randomisation.