Table 2.

LAVA local genetic correlations between GIT disorders, AD, and cognitive traits.

Locus	Chr	Start	Stop	Phenotype 1	Phenotype 2	Parameter	R2	p
1	3	47588462	50387742	GERD	Educational attainment	−0.87	0.76	3.14 × 10−9
	3	47588462	50387742	GERD	FI-Score	−0.98	0.96	6.63 × 10−7
	3	47588462	50387742	GERD	Intelligence	−0.83	0.69	8.72 × 10−7
	3	47588462	50387742	GERD	Educational qualification	−0.76	0.58	3.68 × 10−6
	3	47588462	50387742	GERD	Cognitive performance	−0.82	0.67	5.26 × 10−6
	3	47588462	50387742	GERD	Age of fulltime education	−0.95	0.91	2.69 × 10−5
	3	47588462	50387742	IBD	Educational qualification	0.85	0.72	5.81 × 10−8
	3	47588462	50387742	IBD	Cognitive performance	0.89	0.80	2.83 × 10−7
	3	47588462	50387742	IBD	Educational attainment	0.70	0.49	4.57 × 10−7
	3	47588462	50387742	IBD	Intelligence	0.75	0.56	3.45 × 10−6
2	6	27261036	28666364	GERD	Cognitive performance	−0.78	0.61	4.50 × 10−6
3	6	31106494	31250556	Diverticulosis	Age of fulltime education	−1.00	1.00	2.29 × 10−5
4	6	32454578	32539567	IBD	AD	1.00	1.00	4.80 × 10−7
	6	32454578	32539567	IBD	Educational attainment	0.77	0.59	1.14 × 10−5
	6	32454578	32539567	Diverticulosis	Educational qualification	−1.00	1.00	4.81 × 10−10
	6	32454578	32539567	Diverticulosis	Educational attainment	−1.00	1.00	5.02 × 10−9
	6	32454578	32539567	Diverticulosis	Age of fulltime education	−1.00	1.00	1.51 × 10−7
	6	32454578	32539567	Diverticulosis	AD	−0.92	0.85	8.93 × 10−6
5	6	32539568	32586784	IBD	AD	0.99	0.98	1.10 × 10−8
6	6	98173004	99678876	GERD	Educational attainment	−0.60	0.36	1.65 × 10−6
	6	98173004	99678876	PUD	Cognitive performance	−0.69	0.47	5.90 × 10−7
	6	98173004	99678876	PUD	Intelligence	−0.57	0.32	1.51 × 10−5
	6	98173004	99678876	PUD	FI-Score	−0.64	0.41	1.91 × 10−5
7	11	112755447	113889019	GERD	Educational attainment	−0.87	0.75	1.34 × 10−6
8	13	58245844	59751795	GERD	Educational attainment	−0.65	0.42	7.79 × 10−6
	13	58245844	59751795	GERD	Cognitive performance	−0.83	0.69	1.12 × 10−5
9	14	22760701	23985936	GD	Cognitive performance	−0.81	0.66	1.05 × 10−5
	14	22760701	23985936	GD	Age of fulltime education	−1.00	1.00	4.22 × 10−5
10	15	96864279	98025684	GD	Educational qualification	−0.60	0.36	3.49 × 10−5
11	16	27443062	29043177	IBD	FI Chained arithmetic	−0.77	0.59	1.30 × 10−7
12	16	53393883	54866095	GD	Cognitive performance	−0.72	0.51	1.23 × 10−5
	16	53393883	54866095	GERD	Intelligence	−0.52	0.27	3.22 × 10−6
	16	53393883	54866095	GERD	Cognitive performance	−0.57	0.33	7.08 × 10−6
13	17	45883902	47516224	GERD	Cognitive performance	−0.80	0.65	1.16 × 10−5
14	19	45040933	45893307	GERD	AD	−0.40	0.16	3.78 × 10−5

Chr: chromosome, PUD: peptic ulcer disease, GERD: gastroesophageal reflux disease, IBD: inflammatory bowel disease, GD: gastritis-duodenitis, AD: Alzheimer’s disease, FI-Chained arithmetic: fluid intelligence-chained arithmetic, p: p-value, LAVA: local analysis of [co]variant association.