Table 6.
Results of bidirectional MR-PRESSO analysis for IBD and cognitive traits.
| Exposure (nSNPs) | Outcome | MR-PRESSO RESULTS | MR-Egger Intercept | |||||
|---|---|---|---|---|---|---|---|---|
| Global Test P | Raw OR | p | Cor-OR | p | Intercept | p | ||
| Cognitive traits (exposure) and IBD (outcome) | ||||||||
| Age of fulltime education (11) | IBD | 2 × 10−4 | 1.33 | 0.30 | 1.06 | 0.73 | −0.019 | 0.72 |
| Educational qualification (103) | IBD | <2 × 10−4 | 1.05 | 0.61 | 0.98 | 0.81 | −0.024 | 0.023 |
| Intelligence (166) | IBD | 4 × 10−4 | 0.94 | 0.46 | 0.96 | 0.61 | −0.0094 | 0.26 |
| FI Chained arithmetic (22) * | IBD | 0.60 | 0.95 | 0.34 | - | - | 0.00088 | 0.94 |
| FI Cond arithmetic (23) * | IBD | 0.66 | 1.03 | 0.60 | - | - | 0.0065 | 0.60 |
| FI−famRelatCal (28) | IBD | 0.23 | 0.99 | 0.89 | - | - | 0.0051 | 0.70 |
| Fluid intelligence score (47) | IBD | 0.006 | 1.06 | 0.36 | 1.02 | 0.70 | 0.0032 | 0.87 |
| FI−Word interpolation (5) | IBD | 0.36 | 1.08 | 0.59 | - | - | 0.30 | 0.13 |
| Cognitive performance (133) | IBD | 4 × 10−4 | 0.88 | 0.20 | 0.87 | 0.11 | 0.0053 | 0.55 |
| Educational attainment (294) | IBD | 0.0018 | 0.90 | 0.25 | 0.85 | 0.067 | −0.0051 | 0.32 |
| IBD (exposure) and cognitive traits (outcome) | ||||||||
| IBD (25) | Age of fulltime education | 0.091 | 0.99 | 0.43 | - | - | −0.00060 | 0.90 |
| IBD (25) | Educational qualification | 0.0046 | 1.00 | 0.60 | 0.99 | 0.23 | 0.0014 | 0.68 |
| IBD (25) | Intelligence | 0.006 | 1.00 | 0.94 | 1.00 | 0.61 | 0.00086 | 0.73 |
| IBD (25) | FI Chained arithmetic | 0.077 | 1.03 | 0.31 | - | - | −0.0066 | 0.51 |
| IBD (25) | FI Cond arithmetic | 0.178 | 1.00 | 0.97 | - | - | 0.0073 | 0.34 |
| IBD (25) | FI−famRelatCal | 0.027 | 1.01 | 0.48 | - | - | 0.0071 | 0.35 |
| IBD (25) | Fluid intelligence score | 0.0012 | 0.99 | 0.72 | - | - | 0.0055 | 0.45 |
| IBD (25) | FI−Word interpolation | 0.24 | 0.98 | 0.43 | - | - | 0.0013 | 0.85 |
| IBD (25) | Cognitive performance | 2 × 10−4 | 1.00 | 0.94 | 1.00 | 0.70 | 5.0 × 10−5 | 0.99 |
| IBD (25) | Educational attainment | 0.0228 | 0.99 | 0.15 | 0.99 | 1.29 × 10−2 | 0.00068 | 0.63 |
nSNP: number of SNPs utilised as instrumental variables, SNP: single nucleotide polymorphism, IBD: inflammatory bowel disease, FI Chained arithmetic: fluid intelligence-chained arithmetic, FI Cond arithmetic: fluid intelligence-conditional arithmetic, FI−famRelatCal: fluid intelligence-family relationship calculation, FI−Word interpolation: fluid intelligence-word interpolation, IVW: inverse variance weighted, p: p-value, MR-PRESSO: Mendelian randomisation pleiotropy residual sum and outlier, OR: odds ratio, Cor-OR: corrected odds ratio, * instrumental variables were selected at psnp < 1 × 10−5. Note spaces marked with a dash indicate that there were no outlier SNPs, and hence, there were no outlier corrected results in the MR-PRESSO analysis.