Table 1.

Synthesis of the molecular characteristics that give plazomicin resistance to AMEs.

Plazomicin Molecular Characteristics	Protection against AMEs Conferred from the Molecular Characteristics	Traditional Aminoglycosides Inactivated by AMEs
Lacks hydroxyl groups in the 3′ and 4′ positions	O-nucleotidyltransferase (ANT(4′))	Amikacin and tobramycin
	O-phosphotransferase (APH(3′))	Amikacin
Presence of unsaturated hydroxyethyl group at position 6′	N-acetyltransferase (AAC(6′))	Amikacin, gentamicin and tobramycin
N-1 substitution with 4-amino-2-hydroxybutanoic acid	N-acetyltransferase (AAC(3′))	Gentamicin and tobramycin
	O-nucleotidyltransferase (ANT(2′))	Gentamicin and tobramycin
	O-phosphotransferase (APH(2′))	Amikacin, gentamicin, and tobramycin