Figure 5.

(A–C) The preparative strategy of VEGF-loaded 3D porous bacterial cellulose/gelatin scaffolds modified with heparin for vascularization and tissue regeneration purposes. After the condensation of the -COOH in the heparin and the -NH₂ in the gelatin, the scaffolds could be prepared for (D) subcutaneous transplantation to provide enhanced angiogenesis. NHS: N-hydroxysulfosuccinimide; EDC: 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride; B/G: bacterial cellulose/gelatin; H: heparin. Adapted from reference [80] with permission. Copyright 2017 Elsevier.