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Plasma concentration–time profiles of REM-CAP (remdesivir-Captisol®; 80/20 w/w) and REM-LEU (remdesivir-leucine; 80/20 w/w) after a single inhalation administration in hamsters; (A) remdesivir; (B) GS-441524. The dashed line and dotted line represent the EC50 of remdesivir and GS-441524 in human epithelial cells (HAE) and a continuous human lung epithelial cell line (Calu-3), respectively. Reproduced from Sahakijpijarn et al. [46] with kind permission of copyright holder, Elsevier.
