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. 2022 Dec 9;13:1012824. doi: 10.3389/fimmu.2022.1012824

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Copyright © 2022 Boada, Fatou, Belperron, Sigdel, Smolen, Wurie, Levy, Ronca, Murray, Liberto, Rashmi, Kerwin, Montgomery, Bockenstedt, Steen and Sarwal

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein Expression across Lyme Disease Timepoints. Serum samples from LD patients were assessed by the dHSP platform. The limma package was used to identify differentially expressed proteins in a combined dataset of healthy controls and patients with statistically significant proteins defined with FDR ¾= 0.05. (A) Normalized heatmap displays the progression of abundant proteins (n=46) in both disseminated and localized infections at month 0, 1, and 3 (M0, M1, M3) compared to healthy controls. (B) Normalized heatmap displays the progression of abundant proteins (n = 66) in localized infections at month 0, 1, and 3 (M0, M1, M3). (C) Normalized heatmap displays the progression of abundant proteins (n = 22) in disseminated infections at month 0, 1, and 3 (M0, M1, M3).