Table 3.
White Matter Coherence Following 3 and 6 Months of Medical Cannabis Treatment: Autoregressive Linear Mixed Models (Two-Tailed)
| Mixed model Main effect: visit |
Baseline (n=37) (ref.) |
3 Months (n=31) |
6 Months (n=22) |
|
|---|---|---|---|---|
| F, p | Mean [95% CI] | Estimate [95% CI] Significance | Estimate [95% CI] Significance | |
| Fractional anisotropy | ||||
| Left genu | F = 6.022, p=0.004 | 0.549 [0.533, 0.566] |
0.013 [<0.001, 0.026] t=2.076, p=0.043, d=0.348 |
0.032 [0.014, 0.050]
t=3.467, p=0.001, d=0.711 |
| Right genu | F = 4.446, p=0.016 | 0.545 [0.527, 0.562] |
0.016 [0.002, 0.031] t=2.213, p=0.031, d=0.369 |
0.030 [0.009, 0.051]
t=2.887, p=0.005, d=0.653 |
| Left corona radiata | F=1.441, p=0.246 | 0.399 [0.386, 0.412] | 0.007 [−0.002, 0.015] t=1.479, p=0.145, d=0.078 |
0.010 [−0.003, 0.023] t=1.530, p=0.131, d=0.237 |
| Right corona radiata | F=3.460, p=0.039 | 0.402 [0.390, 0.415] |
0.010 [0.002, 0.018]
t=2.449, p=0.018, d=0.189 |
0.013 [0.001, 0.025] t=2.201, p=0.031, d=0.300 |
| Left external capsule | F=1.946, p=0.153 | 0.386 [0.378, 0.394] | 0.004 [−0.002, 0.011] t=1.343, p=0.185, d=0.142 |
0.009 [<0.001, 0.018] t=1.948, p=0.056, d=0.391 |
| Right external capsule | F=3.008, p=0.058 | 0.381 [0.371, 0.390] | 0.007 [<0.001, 0.015] t=1.993, p=0.052, d=0.233 |
0.012 [0.002, 0.023]
t=2.291, p=0.025, d=0.469 |
| Left anterior limb | F=2.540, p=0.088 | 0.490 [0.478, 0.502] | 0.008 [−0.003, 0.019] t=1.517, p=0.135, d=0.195 |
0.017 [0.002, 0.032] t=2.222, p=0.029, d=0.618 |
| Right anterior limb | F = 4.012, p=0.024 | 0.499 [0.488, 0.510] | 0.005 [−0.004, 0.014] t=1.082, p=0.284, d=0.106 |
0.018 [0.005, 0.030]
t=2.777, p=0.007, d=0.656 |
| Left control region | F=0.067, p=0.935 | 0.547 [0.532, 0.561] | 0.001 [−0.006, 0.008] t=0.275, p=0.785, d=0.098 |
0.002 [−0.009, 0.012] t=0.358, p=0.722, d=0.025 |
| Right control region | F=0.186, p=0.830 | 0.531 [0.515, 0.548] | 0.001 [−0.007, 0.008] t=0.215, p=0.831, d=0.035 |
−0.002 [−0.013, 0.009] t=0.332, p=0.741, d=0.021 |
| Mean diffusivity | ||||
| Left genu | F = 25.553, p < 0.001 | 7.74E-4 [6.82E-4, 8.12E-4] | <0.01E-4 [−0.46E-4, 0.46E-4] t=0.004, p=0.997, d=0.122 |
−1.89E-4 [−2.44E-4, −1.34E-4] t=6.910, p < 0.001, d=1.212 |
| Right genu | F = 30.079, p < 0.001 | 7.41E-4 [6.77E-4, 8.05E-4] | 0.006E-4 [−0.39E-4, 0.50E-4] t=0.247, p=0.806, d=0.125 |
−1.96E-4 [−2.49E-4, −1.42E-4] t=7.373, p < 0.001, d=1.267 |
| Left corona radiata | F = 32.590, p < 0.001 | 6.16E-4 [5.60E-4, 6.72E-4] | 0.05E-4 [−0.29E-4, 0.38E-4] t=0.288, p=0.775, d=0.121 |
−1.79E-4 [−2.26E-4, −1.33E-4] t=7.761, p < 0.001, d=1.372 |
| Right corona radiata | F = 30.508, p < 0.001 | 6.15E-4 [5.61E-4, 6.69E-4] | −0.03E-4 [−0.45E-4, 0.38E-4] t=0.167, p=0.868, d=0.091 |
−1.75E-4 [−2.22E-4, −1.29E-4] t=7.588, p < 0.001, d=1.350 |
| Left external capsule | F = 27.530, p < 0.001 | 6.38E-4 [5.88E-4, 6.88E-4] | 0.08E-4 [−0.41E-4, 0.58E-4] t=0.345, p=0.732, d=0.134 |
−1.53E-4 [−2.02E-4, −1.05E-4] t=6.368, p < 0.001, d=1.233 |
| Right external capsule | F = 26.639, p < 0.001 | 6.31E-4 [5.81E-4, 6.81E-4] | 0.06E-4 [−0.43E-4, 0.55E-4] t=0.247, p=0.806, d=0.133 |
−1.52E-4 [−1.99E-4, −1.05E-4] t=6.537, p < 0.001, d=1.236 |
| Left anterior limb | F = 25.111, p < 0.001 | 6.03E-4 [5.56E-4, 6.51E-4] | −0.03E-4 [−0.56E-4, 0.50E-4] t=0.109, p=0.914, d=0.052 |
−1.54E-4 [−2.01E-4, −1.06E-4] t=6.477, p < 0.001, d=1.279 |
| Right anterior limb | F = 24.207, p < 0.001 | 6.08E-4 [5.61E-4, 6.56E-4] | −0.06E-4 [−0.61E-4, 0.49E-4] t=0.213, p=0.832, d=0.045 |
−1.51E-4 [−1.98E-4, −1.05E-4] t=6.505, p < 0.001, d=1.293 |
| Left control region | F=0.981, p=0.383 | 8.01E-4 [7.82E-4, 8.20E-4] | −0.07E-4 [−0.18E-4, 0.04E-4] t=1.308, p=0.198, d=0.024 |
−0.02E-4 [−0.17E-4, 0.13E-4] t=0.266, p=0.791, d=0.092 |
| Right control region | F=0.379, p=0.687 | 8.09E-4 [7.87E-4, 8.31E-4] | −0.04E-4 [−0.17E-4, 0.09E-4] t=0.607, p=0.547, d=0.163 |
−0.08E-4 [−0.25E-4, 0.10E-4] t=0.871, p=0.387, d=0.227 |
Bold numbers are significant at Bonferroni-corrected p≤0.025. Italicized numbers are findings that did not survive Bonferroni correction p≤0.050. Significance is only noted for estimates relative to the baseline reference group.