Table 5.
Pilot Data of White Matter Coherence Following 3 Months of Treatment-As-Usual: Autoregressive Linear Mixed Models (Two-Tailed)
| Mixed model Main effect: visit |
Baseline (n=14) (ref.) |
3 Months (n=12) |
|
|---|---|---|---|
| F, p | Mean [95% CI] | Estimate [95% CI] Significance | |
| Fractional anisotropy | |||
| Left genu | F=1.847, p=0.201 | 0.532 [0.499, 0.564] | 0.007 [−0.005, 0.019] t=1.359, p=0.201, d=0.282 |
| Right genu | F=2.635, p=0.133 | 0.529 [0.499, 0.559] | 0.008 [−0.003, 0.020] t=1.623, p=0.133, d=0.292 |
| Left corona radiata | F=0.967, p=0.345 | 0.394 [0.371, 0.416] | 0.009 [−0.011, 0.028] t=0.984, p=0.345, d=0.292 |
| Right corona radiata | F=0.202, p=0.662 | 0.392 [0.368, 0.417] | 0.004 [−0.016, 0.024] t=0.449, p=0.662, d=0.239 |
| Left external capsule | F=0.003, p=0.954 | 0.366 [0.343, 0.388] | <0.001 [−0.017, 0.018] t=0.059, p=0.954, d=0.016 |
| Right external capsule | F=1.061, p=0.325 | 0.336 [0.291, 0.381] | −0.006 [−0.020, 0.007] t=1.030, p=0.325, d=0.059 |
| Left anterior limb | F=3.100, p=0.106 | 0.463 [0.430, 0.496] | 0.020 [−0.005, 0.045] t=1.761, p=0.106, d=0.497 |
| Right anterior limb | F=0.135, p=0.720 | 0.478 [0.449, 0.508] | −0.004 [−0.027, 0.019] t=0.368, p=0.720, d=0.045 |
| Left control region | F=3.406, p=0.092 | 0.556 [0.523, 0.589] | 0.012 [−0.002, 0.025] t=1.845, p=0.092, d=0.256 |
| Right control region | F=2.816, p=0.122 | 0.528 [0.493, 0.562] | 0.007 [−0.002, 0.015] t=1.678, p=0.122, d=0.335 |
| Mean diffusivity | |||
| Left genu | F=2.977, p=0.119 | 6.35E-4 [5.07E-4, 7.63E-4] | −0.16E-4 [−0.36E-4, 0.05E-4] t=1.725, p=0.119, d=0.322 |
| Right genu | F=0.519, p=0.487 | 6.17E-4 [5.02E-4, 7.32E-4] | −0.086E-4 [−0.33E-4, 0.17E-4] t=0.720, p=0487, d=0.193 |
| Left corona radiata | F=0.923, p=0.357 | 4.28E-4 [3.74E-4, 4.82E-4] | −0.05E-4 [−0.16E-4, 0.06E-4] t=0.961, p=0.357, d=0.015 |
| Right corona radiata | F=1.379, p=0.264 | 4.26E-4 [3.71E-4, 4.81E-4] | −0.06E-4 [−0.17E-4, 0.05E-4] t=1.174, p=0.264, d=0.025 |
| Left external capsule | F=0.707, p=0.418 | 4.73E-4 [4.17E-4, 5.25E-4] | −0.06E-4 [−0.22E-4, 0.10E-4] t=0.841, p=0.418, d=0.021 |
| Right external capsule | F=0.014, p=0.907 | 4.75E-4 [4.23E-4, 5.271E-4] | 0.01E-4 [−0.15E-4, 0.17E-4] t=0.120, p=0.907, d=0.042 |
| Left anterior limb | F=3.159, p=0.103 | 4.49E-4 [3.95E-4, 5.02E-4] | −0.21E-4 [−0.46E-4, 0.05E-4] t=1.777, p=0.103, d=0.205 |
| Right anterior limb | F=2.205, p=0.166 | 4.31E-4 [3.79E-4, 4.82E-4] | −0.14E-4 [−0.36E-4, 0.07E-4] t=1.485, p=0.166, d=0.134 |
| Left control region | F=2.844, p=0.119 | 7.88E-4 [7.58E-4, 8.18E-4] | −0.14E-4 [−0.32E-4, 0.04E-4] t=1.686, p=0.119, d=0.316 |
| Right control region | F=0.050, p=0.828 | 7.89E-4 [7.56E-4, 8.22E-4] | −0.02E-4 [−0.25E-4, 0.20E-4] t=0.223, p=0.828, d=0.138 |
Bold numbers are significant at Bonferroni-corrected p≤0.025. Italicized numbers are findings that did not survive Bonferroni correction p≤0.050.