Table 1.
Summarized information on curcumin analogs.
| Compd. | Cell Lines Tested IC50 (µM) |
Reference Molecules IC50 (µM) |
Pathway/ Mechanism |
Regulation | Cell Cycle Arrest (Phase) |
[Ref] |
|---|---|---|---|---|---|---|
| 1 | MCF-7 13.1 ± 1.6 MCF-7R 12.0 ± 2.0 |
MCF-7 (CUR) 29.3 ± 1.7 MCF-7R (CUR) 26.2 ± 1.6 |
NF-κB STAT3 |
Bcl-2↓ Bcl-XL↓ c-IAP-1↓ XIAP↓ NAIP↓ Survivin↓ COX-2↓ |
S | [18] |
| 2 | MCF-7 2.56 MDA-MB-231 3.37 |
MCF-7 (CUR) 21.22 MDA-MB-231 (CUR) 26.9 |
STAT3 | MMP-9↓ MMP-2↓ Mcl-1↓ Cyclin D1↓ c-myc↓ Bcl-XL↓ Bcl-2↓ Survivin↓ VEGF↓ |
G1 | [19] |
| 3 | MCF-7 30 |
MCF-7 (CUR) 30 |
NF-κB P13K/Akt |
NF-κB p65↓ c-Rel↓ src↓ COX-2↓ MMP-9↓ TIMP-2↑ VEGF↓ TNFα↓ IL-1β↓ TGF-β↓ IL-8↓ |
NA | [21] |
| 4 | NA | NA | HER2 P13K/Akt ERK1/2 |
NA | G2/M | [22] |
| 5 | MCF-7 18 |
MCF-7 (Tamoxifen) 4 |
HER2 | Cyclin D1↓ Survivin↓ Bcl-2↓ CDC2↓ |
NA | [23] |
| 6j | MCF-7 15 |
NA | NA | Bcl-2↓ | NA | [24] |
| 7i | MCF-7 10 |
NA | NA | Bcl-2↓ | NA | [24] |
| 8a | MCF-7 20 * |
MCF-7 (DOX) 13 |
NA | NA | G2/M | [25] |
| 9 | SKBR3 1.71 ± 0.10 MDA-MB-231 4.49 ± 0.46 MCF-7 9.09 ± 0.46 MDA-MB-453 10.42 ± 0.92 |
SKBR3 (Cisplatin) 3.04 ± 0.17 MDA-MB-231 (Cisplatin) 12.81 ± 0.58 MCF-7 (Cisplatin) 11.16 ± 0.60 MDA-MB-453 (Cisplatin) 15.43 ± 0.83 |
NA | NA | NA | [26] |
| 10 | MCF-7 8.84 MDA-MB-231 8.31 |
MCF-7 (CUR) 16.85 MDA-MB-231 (CUR) 42.01 |
NA | p21↑ Cyclin D1↓ CDK2↓ Bax↑ Cyto-C↑ Bcl-2↓ VEGF↓ TIMP1↑ TIMP2↑ |
G1 | [27] |
| 12b | MDA-MB-231 4.99 ± 1.02 |
MDA-MB-231 (Cisplatin) 6.18 ± 0.79 |
NA | NA | NA | [29] |
| 13 | MCF-7 0.317 MDA-MB-231 0.473 HS 578T 0.295 BT-549 0.693 T-47D 0.79 MDA-MB-468 0.248 |
NA | EGFR | NA | NA | [30] |
| 14 | MCF-7 0.162 MDA-MB-231 0.404 HS 578T 0.0779 BT-549 0.631 T-47D 0.793 MDA-MB-468 0.276 |
NA | EGFR | NA | NA | [30] |
| 15 | MCF-7 1.81 MDA-MB-231 1.45 HS 578T 0.524 BT-549 1.3 T-47D 2.83 |
NA | EGFR | NA | NA | [30] |
| 16 | MCF-7 2.7 ± 0.5 MDA-MB-231 1.5 ± 0.1 |
MCF-7 (CUR) 21.5 ± 4.7 MDA-MB-231 (CUR) 25.6 ± 4.8 |
NA | NA | NA | [31] |
| 17 | MCF-7 0.4 ± 0.1MDA-MB-231 0.6 ± 0.1 |
MCF-7 (CUR) 21.5 ± 4.7 MDA-MB-231 (CUR) 25.6 ± 4.8 |
NA | NA | NA | [31] |
| 18 | MCF-7 2.4 ± 1.0 MDA-MB-231 2.4 ± 0.4 |
MCF-7 (CUR) 21.5 ± 4.7 MDA-MB-231 (CUR) 25.6 ± 4.8 |
NA | NA | NA | [31] |
| 19b | MCF-7 1.97 ** MDA-MB-231 3.06 ** HS 578T 5.10 ** BT-549 1.96 ** T-47D 2.81 ** MDA-MB-468 2.30 ** |
NA | EGFR | NA | NA | [32] |
* µg/mL, ** GI50.