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. 2022 Dec 13;11(24):7388. doi: 10.3390/jcm11247388

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mean, SD and range values of VO₂ peak (upper panel) and of VE/VCO₂ slope (lower panel) in 13 Long-COVID patients with T_I/T_TOT ≤ 0.38 and in 29 Long-COVID patients with T_I/T_TOT > 0.38 at peak of exercise. Sing et al. [19] also demonstrated a hyperventilatory response during exercise in all patients. Similarly, in a large cohort of patients at approximately three months after the initial diagnosis of SARS-CoV-2 infection, Motiejunaite et al. [5] found an elevated VE/VCO₂ slope in one third of the study participants, suggesting a high incidence of inadequate ventilation on exertion. In the current study, LC patients had higher values in VE/VCO₂ slope, as compared to controls, but they did not differ in terms of PETCO₂, thereby showing ventilatory inefficiency without hyperventilation.

Mean, SD and range values of VO₂ peak (upper panel) and of VE/VCO₂ slope (lower panel) in 13 Long-COVID patients with T_I/T_TOT ≤ 0.38 and in 29 Long-COVID patients with T_I/T_TOT > 0.38 at peak of exercise. Sing et al. [19] also demonstrated a hyperventilatory response during exercise in all patients. Similarly, in a large cohort of patients at approximately three months after the initial diagnosis of SARS-CoV-2 infection, Motiejunaite et al. [5] found an elevated VE/VCO₂ slope in one third of the study participants, suggesting a high incidence of inadequate ventilation on exertion. In the current study, LC patients had higher values in VE/VCO₂ slope, as compared to controls, but they did not differ in terms of PETCO₂, thereby showing ventilatory inefficiency without hyperventilation.