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Biosynthesis and hydrolysis of N–Arachidonoylethanolamine (AEA) pathway. Abbreviations in red mean the enzymes: NAT: N–acyltransferase; sPLA2: soluble phospholipase A2; PLC: phospholipase C; ABHD4: α/β–hydrolase domain 4; GDE1: glycerophosphodiesterase; NAPE–PLD: NAPE–specific phospholipase D; PTPN22: non–receptor protein tyrosine phosphatase 22; FAAH: fatty acid amide hydrolase.
