Table 2.

Univariate and multivariate analysis for OS in patients with ICC.

Variables	Overall Survival Univariate Analysis			Overall Survival Multivariate Analysis
	HR	95% CI	p-Value	HR	95% CI	p-Value
Age (≥56 vs. <56)	1.725	0.916–3.248	0.091
Gender (male vs. female)	0.977	0.718–1.330	0.883
Cirrhosis (yes vs. no)	1.146	0.614–2.138	0.669
Tumor number (multiple vs. single)	1.757	0.953–3.239	0.071
Tumor size (>5 cm vs. ≤5 cm)	1.800	0.963–3.364	0.065
Vascular invasion	2.992	1.615–5.543	<0.001 *	2.347	1.216–4.530	0.011 *
Pathology microvascular invasion	1.311	0.681–2.523	0.418
Pathology nerve tract invasion	2.846	1.490–5.437	0.002 *	3.018	1.536–5.927	0.001 *
Pathology differentiation degree (Moderate to poor, poor vs. well, well to moderate, moderate)	1.483	0.719–3.056	0.286
AFP (≥25 vs. <25)	1.236	0.521–2.935	0.631
CA19-9 (≥35 vs. <35)	2.653	1.410–4.989	0.002 *	2.071	1.030–4.167	0.041 *
CEA (≥5 vs. <5)	3.384	1.818–6.300	<0.001 *	1.965	0.880–3.746	0.107
PIVKA-II (≥40 vs. <40)	0.463	0.182–1.180	0.107
History of cholelithiasis	1.660	0.909–3.032	0.099
Hepatitis B	0.920	0.502–1.687	0.788
HALP (≥43.63 vs. <43.63)	1.258	0.662–2.391	0.483
NLR (≥3.73 vs. <3.73)	0.475	0.238–0.946	0.034 *	1.463	0.691–3.098	0.320
PLR (≥76.51 vs. <76.51)	0.217	0.030–1.580	0.132

Notes: * p < 0.05.