Table 9.
Cox’s proportional hazard model for distant metastasis-free survival (DMFS) in patients with stage III melanomas and 5 years of follow-up.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| Variable | Coef | HR (95% CI) |
p-Value | Coef | HR (95% CI) |
p-Value |
| Men and women | ||||||
| Age | 0.0359 | 1.0365 (1.002–1.073) |
0.0404 | 0.0520 | 1.0534 (1.015–1.093) |
0.0061 |
| Sex | 0.9262 | 2.5249 (0.828–7.704) |
0.1040 | - | - | - |
| Breslow thickness | 0.0980 | 1.1029 (0.992–1.226) |
0.0693 | - | - | - |
| Ulceration | 0.8022 | 2.2305 (0.842–5.907) |
0.1060 | - | - | - |
| Melanoma subtypes | 0.0077 | 1.0078 (0.680–1.494) |
0.9690 | - | - | - |
| rs1042602 genotype | −1.1387 | 0.3202 (0.127–0.809) |
0.0160 | −1.5605 | 0.2100 (0.079–0.555) |
0.0017 |
| Men | ||||||
| Age | 0.0340 | 1.0346 (0.997–1.074) |
0.0719 | - | - | - |
| Breslow thickness | 0.0887 | 1.0928 (0.983–1.215) |
0.1 | - | - | - |
| Ulceration | 1.1984 | 3.3148 (1.075–10.22) |
0.037 | 1.7475 |
5.7401 (1.594–20.657) |
0.0075 |
| Melanoma subtypes | 0.1234 | 1.1313 (0.752–1.702) |
0.5540 | - | - | - |
| rs1042602 genotype | −1.3253 | 0.2657 (0.090–0.787) |
0.0168 | −1.8709 | 0.154 (0.044- 0.539) |
0.0034 |
Dash indicates not included in multivariate analysis due to lack of significance in univariate analysis. Coef, beta coefficient; HR, hazard ratio; CI, confidence interval.