Table 1.
Basic characteristics of study subjects.
| All-Cause ALRI (N = 942) | RSV-Associated ALRI (N = 282) | |||||
|---|---|---|---|---|---|---|
| 1 January 2018 to 16 March 2020 (N = 592) | 17 March 2020 to 30 June 2022 (N = 350) | p Value | 1 January 2018 to 16 March 2020 (N = 183) | 17 March 2020 to 30 June 2022 (N = 99) | p Value | |
| Sex, N (%) | 0.539 a | 0.436 a | ||||
| Male | 347 (58.6) | 198 (56.6) | 104 (56.8) | 61 (61.6) | ||
| Female | 245 (41.4) | 152 (43.4) | 79 (43.1) | 38 (38.4) | ||
| Age group, N (%) | <0.001 a | 0.154 a | ||||
| 0–<28 d | 30 (5.7) | 52 (14.8) | 14 (7.7) | 17 (17.2) | ||
| 28 d–<3 m | 212 (35.8) | 121 (34.6) | 94 (51.4) | 45 (45.5) | ||
| 3–<6 m | 126 (21.3) | 67 (19.1) | 45 (24.6) | 23 (23.2) | ||
| 6–<12 m | 93 (15.7) | 44 (12.6) | 21 (11.5) | 8 (8.1) | ||
| 12–<24 m | 131 (22.1) | 66 (18.9) | 9 (4.9) | 6 (6.1) | ||
| Gestational age, N (%) | 0.200 a | 0.723 a | ||||
| <28 w | 10 (1.7) | 5 (1.4) | 2 (1.1) | 0 (0.0) | ||
| 28–<32 w | 10 (1.7) | 7 (2.0) | 3 (1.6) | 1 (1.0) | ||
| 32–<37 w | 48 (8.1) | 43 (12.3) | 22 (12.0) | 13 (13.1) | ||
| ≥37 w | 524 (88.5) | 295 (84.3) | 156 (85.2) | 85 (85.9) | ||
| Birth weight, median (IQR) | 3470 (3060, 3820) |
3420 (3000, 3737.5) |
0.341 a | 3470 (2980, 3820) |
3480 (3010, 3810) |
0.931 b |
| Birth height, median (IQR) | 50.5 (49, 52) |
50 (49, 51.8) |
0.023 b | 50 (49, 52) |
50 (48, 51) |
0.261 b |
| Comorbidity, N (%) | ||||||
| Any | 43 (7.3) | 47 (13.4) | 0.002 a | 10 (5.5) | 6 (6.1) | 0.836 c |
| Congenital heart disease | 16 (2.7) | 25 (7.1) | 0.001 c | 5 (2.7) | 5 (5.1) | 0.315 c |
| Chronic pulmonary disease | 15 (2.5) | 15 (4.3) | 0.139 c | 3 (1.6) | 1 (1.0) | - |
| Neuromuscular disease | 2 (0.3) | 1 (0.3) | - | 0 (0.0) | 0 (0.0) | - |
| Immunodeficiency | 1 (0.2) | 0 (0.0) | - | 1 (0.5) | 0 (0.0) | - |
| Down syndrome | 9 (1.5) | 6 (1.7) | 0.818 c | 1 (0.5) | 0 (0.0) | - |
| Severity of ALRI, N (%) | ||||||
| Severe | 17 (2.9) | 29 (8.3) | <0.001 a | 3 (1.6) | 10 (10.1) | <0.001 c |
| Very severe | 14 (2.4) | 14 (4.0) | 0.153 a | 3 (1.6) | 6 (6.1) | 0.044 c |
| Length of hospital stay in days, median (IQR) | 5 (4, 7) | 6 (4, 8) | <0.001 b | 6 (4, 8) | 7 (5, 8) | 0.039 b |
Note: ALRI, acute lower respiratory infection; RSV, respiratory syncytial virus. a p-value calculated by Chi-square test, b p-value calculated by Mann-Whitney U test, c p-value calculated by Fisher’s exact test.