Table 4.
Joint effect and interaction between metformin and pioglitazone on inflammatory bowel disease.
| Metformin/Pioglitazone Use | Incident Case Number |
Cases Followed |
Person-Years | Incidence Rate (per 100,000 Person-Years) |
Hazard Ratio | 95% Confidence Interval |
p Value |
|---|---|---|---|---|---|---|---|
| Metformin (−)/Pioglitazone (−) | 33 | 3382 | 8911.51 | 370.31 | 1.000 | ||
| Metformin (−)/Pioglitazone (+) | 27 | 3374 | 8986.75 | 300.44 | 0.840 | (0.503–1.402) | 0.5043 |
| Metformin (+)/Pioglitazone (−) | 106 | 9381 | 25,076.80 | 422.70 | 1.186 | (0.793–1.771) | 0.4061 |
| Metformin (+)/Pioglitazone (+) | 86 | 9389 | 25,167.85 | 341.71 | 0.950 | (0.630–1.433) | 0.8074 |
| P-interaction | 0.6002 |