Table 5.
Summarized information on UA analogs (C3 and C28 modifications).
| Compound | Pathway/Mechanism | Regulation | Cell Cycle Arrest (Phase) | Animal Study | [Ref] |
|---|---|---|---|---|---|
| 26 | Activation of caspase-3 | Apoptosis | S | yes | [85] |
| 29 | Activation of the caspase-3 mitochondria pathway |
Bcl2↓ Survivin↓ |
NA | yes | [89] |
| 31 | Activation of caspases-8, -9, and -3 | Bcl2↓ HKII↓ Bax↑ p53↑ |
S G2/M |
yes | [96] |
| 32 | NA | NA | G0/G1 | no | [97] |
| 33 | Activation of caspases-8, -9, and -3 Increased production of reactive oxygen species (ROS) |
Bcl2↓ | G1 | no | [98] |
| 36 | NF-κB | NA | G1 | no | [100] |