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. 2022 Dec 5;10(12):2078. doi: 10.3390/vaccines10122078

Figure 4.

Figure 4

Influence of TLR2 engagement on post-challenge Th2 and eosinophil response. BALB/c mice were immunized on days 0 and 21 as indicated (day 0 only for live RSV), challenged with live RSV on day 35, and sacrificed on day 41 for harvesting of BAL fluid and cells. All analyses were conducted on day 41 (day 6 post-challenge) BAL samples. (A) BAL RSV G-specific antibody isotype levels measured by ELISA. Mean ± SEM of 6 mice per group at 1:5 BAL dilution. (B) Th2 cytokine content of BAL fluids measured by Luminex. Mean ± SEM of 6 mice per group. * p < 0.05 vs. GM2 and FI-RSV groups for IL-5 and IL-13. (C) Th1/Th17 cytokine content of BAL fluids measured by Luminex. Mean ± SEM of 6 mice per group. (D) Eosinophil counts in BAL. Mean ± SEM of 6 mice per group. * p < 0.05 vs. GM2 and FI-RSV groups.