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. 2022 Dec 14;20(12):779. doi: 10.3390/md20120779

Figure 4.

Figure 4

Effects of dieckol on the MAPK and TGF-β/Smad 2/3 signaling pathway in UVB-irradiated HR-1 mice. HR-1 mice were administered dieckol (5 or 10 mg/kg) three times per week for 8 weeks after UVB irradiation (60 mJ/cm2 to 120 mJ/cm2). The protein expression and phosphorylation level of (A) MAPKs (ERK, JNK, and p-38); (B) p-c-Fos, c-Fos, and (C) TGF- β/Smad 2/3 were evaluated by Western blot analysis and relative densities. β-actin is used as an internal control. Data are expressed as the mean ± SEM (n = 6). # p < 0.05 vs. the vehicle-treated control group; *** p < 0.001 vs. UVB only-treated group.