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. 2022 Dec 17;15(12):1578. doi: 10.3390/ph15121578

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Genome-wide expression analysis of human PBMCs does not demonstrate an aromatase-inhibitor-mediated response. Freshly isolated human PBMCs were stimulated in vitro with estrogen, letrozole, or a combination of both for a comparison relative to untreated control samples. RNA sequencing was preformed to evaluate overall expression levels of mRNA and miRNA targets with each treatment sample. Data from each subject were normalized to control values, and relative expression levels are presented as heatmaps to evaluate genome-wide treatment effects on mRNA (left) and miRNA (right) transcripts.