Table 3.
Geometric mean titers (GMTs) against poliovirus strains.
| Poliovirus Strain | GMT (95%CI) | GMFR | GMFR | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Visit 1 | Visit 2 | Visit 3 | Visit 2/Visit 1 | Visit 3/Visit 2 | |||||||
| Sabin | Sabin 1 | 42.0 | (28.6–60.8) | 745 | (582–944) | 737 | (603–912) | 17.7 | (p < 0.01) | 1.0 | (p = 0.83) |
| Sabin 2 | 44.5 | (32.7–61.1) | 914 | (805–1033) | 883 | (778–1021) | 20.5 | (p < 0.01) | 1.0 | (p = 0.233) | |
| Sabin 3 | 10.4 | (7.57–14.5) | 561 | (411–769) | 536 | (409–705) | 53.9 | (p < 0.01) | 1.0 | (p = 0.148) | |
| Virulent | Mahoney (type 1) |
14.9 | (10.9–20.0) | 643 | (486–818) | 621 | (495–767) | 43.1 | (p < 0.01) | 1.0 | (p = 0.193) |
| MEF-1 (type 2) |
40.2 | (30.2–52.5) | 924 | (834–1045) | 914 | (824–1009) | 23.0 | (p < 0.01) | 1.0 | (p = 0.85) | |
| Saukett (type 3) |
6.90 | (5.40–8.87) | 495 | (352–681) | 478 | (356–643) | 71.7 | (p < 0.01) | 1.0 | (p = 0.606) | |
| Type 2 VDPV |
SV3128 | 55.2 | (40.9–73.8) | 957 | (843–1081) | 957 | (869–1050) | 17.3 | (p < 0.01) | 1.0 | (p = 1.000) |
| SV3130 | 37.5 | (27.7–49.9) | 935 | (824–1057) | 946 | (849–1074) | 24.9 | (p < 0.01) | 1.0 | (p = 0.773) | |
| 11196 | 42.0 | (31.0–56.0) | 904 | (802–1038) | 957 | (851–1072) | 21.5 | (p < 0.01) | 1.1 | (p = 0.037) | |
| 11198 | 24.9 | (18.5–34.1) | 924 | (830–1050) | 864 | (760–998) | 37.1 | (p < 0.01) | 0.9 | (p = 0.047) | |
GMT, geometric mean titer; CI, confidence interval; GMFR, geometric mean fold rise, the geometric mean of the ratios of post-dose antibody to pre-dose antibody; p-values were calculated using the Wilcoxon signed-rank test.