Table 4.
Poliovirus Strain | Participant 1 (One Dose with tOPV) |
Participant 2 (One Dose with tOPV) |
Participant 3 (Unvaccinated with tOPV) |
|||||||
---|---|---|---|---|---|---|---|---|---|---|
Visit 1 | Visit 2 | Visit 3 | Visit 1 | Visit 2 | Visit 3 | Visit 1 | Visit 2 | Visit 3 | ||
Sabin 1 | 128 | >1024 | >1024 | 8 | >1024 | >1024 | <4 | <4 | 16 | |
Sabin | Sabin 2 | 128 | >1024 | >1024 | 8 | 512 | 512 | <4 | 32 | 32 |
Sabin 3 | <4 | 64 | 128 | 8 | >1024 | >1024 | <4 | <4 | 128 | |
Mahoney (type 1) | 8 | >1024 | >1024 | 4 | 1024 | 1024 | <4 | 4 | 128 | |
Virulent | MEF-1 (type 2) | 64 | >1024 | >1024 | 4 | >1024 | >1024 | <4 | 64 | 128 |
Saukett (type 3) | <4 | 64 | 256 | 4 | >1024 | >1024 | <4 | <4 | 64 | |
Type 2 VDPV |
SV3128 | 64 | >1024 | >1024 | 4 | >1024 | 1024 | <4 | 32 | 64 |
SV3130 | 64 | >1024 | >1024 | 4 | >1024 | >1024 | <4 | 32 | 32 | |
11196 | 64 | >1024 | >1024 | 4 | >1024 | 1024 | <4 | 32 | 32 | |
11198 | 64 | >1024 | >1024 | 4 | 512 | 512 | <4 | 32 | 32 |
Participants 1 and 2 had received one dose of tOPV, but participant 3 was unvaccinated with tOPV in childhood. Even one booster dose with cIPV was effective at enhancing antibody titers in participants 1 and 2, but participant 3 needed two doses of cIPV for a seropositive titer against all strains.