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. 2022 Dec 18;15(12):1580. doi: 10.3390/ph15121580

Figure 5.

Figure 5

Anxiolytic-like effects of CAE (10–100 mg/kg p.o.) were measured in the cylinder exploratory test (a) and the hole-board test (b) during a 5 min exposure. The possible mechanism of action of CAE was evaluated in the hole-board test (c). Clonazepam (CNZ) at 1.5 mg/kg p.o. was used as the positive control. Bars represent mean values (± SEM) for the experimental group. n = 8, ** p < 0.05 compared to the vehicle group.