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. 2022 Dec 9;14(12):2753. doi: 10.3390/v14122753

Figure 2.

Figure 2

Expression of genes involved in activated protein C (APC) signaling in the liver from healthy individuals and patients with coronavirus disease 2019 (COVID-19) based on single-cell transcriptomics. (A). Uniform Manifold Approximation and Projection (UMAP) embedding of liver cells via single-cell RNA sequencing (scRNA-Seq) droplet-based single-cell platform, showing single liver parenchymal cells grouped into 36 clusters. (B). Matrix plot showing expression of genes related to APC signaling according to the cell type in a healthy liver. (C). Matrix plot showing expression of genes related to APC signaling in patients with COVID-19 versus healthy individuals. (D). Dot plot representation of downregulated genes in patients with COVID-19. (E). Matrix plot showing expression of genes related to APC signaling according to the cell type in an autopsy liver sample from a patient with COVID-19. (F). Visualization of co-expression (yellow) by color overlap. PROC (red) is barely co-expressed with ACE2 (green) in hepatocyte clusters. (G). Spearman’s correlation of subset of cells that co-expressed PROC and ACE2.