Figure 3.

Maternal diets influence microbiome-metabolomics-epigenetics interplay, resulting in health outcome changes. Maternal diets can alter the gut microbial profile and microbiota-synthesized metabolites. Additionally, the transplacental transfer of maternal intestinal microbes and metabolites to the developing fetus can influence epigenetic reprogramming progresses in fetuses. Principally, this crosstalk influences offspring health outcomes, such as metabolic disease susceptibility, later in life.