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. 2022 Dec 14;23(24):15915. doi: 10.3390/ijms232415915

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Aortic differentially expressed proteins were identified by the iTRAQ approach. HFD up- or down-regulated proteins (versus ND) (A). HFD-LI up- or down-regulated proteins (versus HDF) (B). GO enrichment analyses of the aortic differentially expressed proteins of HFD group versus ND group (C). GO enrichment analyses of the aortic differentially expressed proteins of HFD + LI group versus HFD group (D). GO enrichment analysis revealed the most relevant biological process (BP) terms of proteins up-regulated by HFD (versus ND) (E), proteins down-regulated by HFD (versus ND) (F), proteins up-regulated by HFD-LI (versus HFD) (G), and proteins down-regulated by HFD + LI (versus HFD) (H). Top 10 GO clusters (p < 0.05). GO, Gene Ontology.