. 2022 Dec 11;27(24):8780. doi: 10.3390/molecules27248780

Table 2.

Regression equation coefficients for cold ethanol extraction of cannabis with different experimental conditions.

Response/Dependent Variables		Regression Model Effect Parameters
		Intercept	Linear		Quadratic		Interaction
		β₀	β₁	β₂	β₁₁	β₂₂	β₁₂
Cold ethanol extraction at −20 °C
THC	Coefficient	0.32	0.08	−0.03	−0.03	0.01	0.02
THC	p value	<0.0001 *	0.01 *	0.23	0.25	0.6	0.61
THCA	Coefficient	11.69	2.93	−1.24	−0.79	0.86	0.96
THCA	p value	<0.0001 *	0.01 *	0.13	0.34	0.3	0.38
Total THC	Coefficient	10.57	2.65	−1.12	−0.72	0.77	0.86
Total THC	p value	<0.0001 *	0.01 *	0.13	0.34	0.31	0.39
CBG	Coefficient	0.06	0.01	−0.01	−0.01	0	0.01
CBG	p value	<0.0001 *	0.02 *	0.16	0.35	0.47	0.23
CBGA	Coefficient	0.17	0.05	−0.02	−0.01	0.01	0.01
CBGA	p value	<0.0001 *	0.01 *	0.1	0.29	0.3	0.51
Total CBG	Coefficient	0.2	0.05	−0.02	−0.02	0.01	0.02
Total CBG	p value	<0.0001 *	0.01 *	0.16	0.33	0.35	0.39
THCVA	Coefficient	0.6	0.17	−0.07	−0.04	0.05	0.05
THCVA	p value	<0.0001 *	0 *	0.12	0.39	0.32	0.38
CBCA	Coefficient	0.22	0.06	−0.03	−0.01	0.02	0.02
CBCA	p value	<0.0001 *	0.01 *	0.13	0.41	0.36	0.32
Total terpenes	Coefficient	1.1	0.32	0.26	−0.13	−0.22	−0.11
Total terpenes	p value	<0.0001 *	0.001 *	0.002 *	0.06	0.01 *	0.23
Extraction yield	Coefficient	17.14	4.24	0.14	−2.56	−0.25	0.26
Extraction yield	p value	<0.0001 *	<0.0001 *	0.63	<0.0001 *	0.42	0.53
Cold ethanol extraction at −40 °C
THC	Coefficient	0.34	0.07	−0.01	0.01	0.01	−0.02
THC	p value	<0.0001 *	0.01 *	0.62	0.54	0.68	0.52
THCA	Coefficient	14.34	2.36	−0.43	0.2	−0.49	−0.66
THCA	p value	<0.0001 *	0.03 *	0.63	0.83	0.61	0.60
Total THC	Coefficient	12.91	2.14	−0.39	0.19	−0.42	−0.59
Total THC	p value	<0.0001 *	0.03 *	0.62	0.82	0.62	0.6
CBG	Coefficient	0.07	0.01	0	0	0	−0.01
CBG	p value	<0.0001 *	0.04 *	0.57	0.89	0.51	0.42
CBGA	Coefficient	0.21	0.04	−0.01	0	−0.01	−0.01
CBGA	p value	<0.0001 *	0.03 *	0.64	0.81	0.53	0.51
Total CBG	Coefficient	0.25	0.04	−0.01	0	−0.01	−0.01
Total CBG	p value	<0.0001 *	0.03 *	0.64	0.89	0.56	0.51
THCVA	Coefficient	0.75	0.13	−0.03	0.02	−0.03	−0.04
THCVA	p value	<0.0001 *	0.02 *	0.54	0.75	0.56	0.52
CBCA	Coefficient	0.27	0.05	−0.01	0	−0.01	−0.02
CBCA	p value	<0.0001 *	0.03 *	0.65	0.99	0.69	0.55
Total terpenes	Coefficient	1.16	0.6	0.03	0.17	0.05	−0.04
Total terpenes	p value	<0.0001 *	<0.0001 *	0.73	0.06	0.52	0.73
Extraction yield	Coefficient	17.47	2.87	−0.09	−1.12	0.18	−0.22
Extraction yield	p value	<0.0001 *	0.01 *	0.88	0.12	0.78	0.8
Cold ethanol extraction at room temperature
THC	Coefficient	0.35	0.1	0.02	0.04	0.01	0
THC	p value	<0.0001 *	0.01 *	0.24	0.11	0.58	1
THCA	Coefficient	12.14	3.6	−0.9	1.08	0.33	−0.27
THCA	p value	<0.0001 *	<0.0001 *	0.04 *	0.02 *	0.42	0.61
Total THC	Coefficient	11	3.25	−0.8	0.98	0.3	−0.24
Total THC	p value	<0.0001 *	<0.0001 *	0.04 *	0.03 *	0.4	0.63
CBG	Coefficient	0.06	0.02	0	0.01	0	0
CBG	p value	<0.0001 *	<0.0001 *	0.05	0.01 *	0.55	0.22
CBGA	Coefficient	0.18	0.06	−0.01	0.02	0.01	0
CBGA	p value	<0.0001 *	<0.0001 *	0.03 *	0.02 *	0.42	1
Total CBG	Coefficient	0.22	0.07	−0.02	0.02	0.01	0
Total CBG	p value	<0.0001 *	<0.0001 *	0.04 *	0.03 *	0.43	0.81
THCVA	Coefficient	0.64	0.21	−0.05	0.06	0.01	−0.02
THCVA	p value	<0.0001 *	<0.0001 *	0.02 *	0.03 *	0.51	0.47
CBCA	Coefficient	0.24	0.07	−0.02	0.02	0.01	−0.01
CBCA	p value	<0.0001 *	<0.0001 *	0.04 *	0.02 *	0.53	0.47
Total terpenes	Coefficient	1.02	0.39	0.07	−0.18	0	−0.18
Total terpenes	p value	<0.0001 *	<0.0001 *	0.14	0.01 *	0.97	0.02 *
Extraction yield	Coefficient	17.76	3.16	−0.36	−1.61	−0.39	0.76
Extraction yield	p value	<0.0001 *	<0.0001 *	0.04 *	<0.0001 *	0.04 *	0.01 *

Effects are statistically significant if p value * < 0.05. Model intercept (β₀), linear terms (β₁ and β₂), quadratic terms (β₁₁ and β₂₂), and interaction term (β₁₂) are the model effect parameters.