Table 5.
Particle size obtained by MALS before and after incubation with BSA (Dg by the random coil model) and online DLS (Dh by a cumulant analysis). All values are averaged from 3 different replicates.
| System | Before Incubation | After Incubation with BSA | ||||
|---|---|---|---|---|---|---|
| Dg (nm) | Dh (nm) | Shape Factor (Dg/Dh) | Dg (nm) | Dh (nm) | Shape Factor (Dg/Dh) | |
| PVAL-COOH SPIONs | 79 ± 16 | 97 ± 14 | 0.92 ± 0.26 | 74 ± 5 | 73 ± 9 | 1.02 ± 0.15 |
| PVAL-OH SPIONs | 76 ± 13 | 88 ± 12 | 0.77 ± 0.03 | 46 ± 1 | 70 ± 6 | 0.65 ± 0.06 |
| PVAL-NH2 (+) SPIONs | 151 ± 11 | 129 ± 25 | 1.03 ± 0.08 | 89 ± 2 | 117 ± 8 | 0.77 ± 0.06 |
| PVAL-NH2 (++) SPIONs | No peak detected | |||||