Table 1.
Baseline characteristics and changes after 6 months in the myoinositol and metformin group.
| Intervention | Myoinositol (n = 16) |
Metformin (n = 12) |
|||||
|---|---|---|---|---|---|---|---|
| Time | Baseline | 6 Months | Δ p | Baseline | 6 Months | Δ p | Δ vs. Δ p |
| HOMA-IR (pmol mmol L−2) | 28.5 (19.6;45.6) | 33.7 (27.1;49.6) | 0.31 | 30.9 (24.9;32.4) | 18.8 (14.3;29.6) | 0.11 | 0.09 |
| Insulin (pmol/L) | 126 (85;190) | 119 (78;219) | 0.38 | 117 (112;143) | 80 (65;121) | 0.21 | 0.13 |
| Glucose (mmol/L) | 5.2 (5.0;5.4) | 5.4 (5.3;5.7) | 0.00 | 5.3 (5.1;5.7) | 5.2 (4.8;5.3) | 0.04 | 0.00 |
| HbA1c (mmol/mol) | 32.0 (30.0;36.0) | 33.0 (31.0;34.0) | 0.18 | 33.5 (32.0;35) | 32.0 (31.5;33.5) | 0.47 | 0.12 |
| Triglycerides (mmol/L) | 1.2 (1.0;1.4) | 1.3 (1.0;1.6) | 0.09 | 1.0 (0.9;1.2) | 1.0 (0.8;1.5) | 0.81 | 0.25 |
| HDL (mmol/L) | 1.2 (1.0;1.3) | 1.2 (1.1;1.3) | 0.92 | 1.3 (1.2;1.4) | 1.4 (1.2;1.6) | 0.04 | 0.07 |
| LDL (mmol/L) | 2.9 (2.4;3.2) | 2.9 (2.5;3.1) | 0.44 | 3.1 (2.6;3.3) | 2.9 (2.6;3.3) | 0.93 | 0.64 |
| Cholesterol (mmol/L) | 4.6 (4.1;4.9) | 4.7 (4.1;5.1) | 0.46 | 4.8 (4.3;5.2) | 4.8 (4.2;5.3) | 0.69 | 0.42 |
| Age (years) | 25 (22;34) | - | 27 (24;33) | - | - | ||
| Weight (kg) | 96.7 (84.5;107.6) | 94.4 (84.9;107.0) | 0.98 | 99.8 (86.4;108.9) | 93.7(81.7;106.8) | 0.00 | 0.02 |
| BMI (kg/m2) | 34.2 (30.9;37.2) | 34.5 (29.9;36.8) | 0.96 | 35.2 (31.0;39.8) | 32.8 (29.8;38.5) | 0.00 | 0.02 |
| Waist (cm) | 103 (93;108) | 100 (93;104) | 0.31 | 99 (92;106) | 100 (90;105) | 0.41 | 0.62 |
| Hip (cm) | 122 (108;125) | 119 (110;125) | 0.84 | 123 (114;129) | 119 (110;128) | 0.06 | 0.11 |
| Cycle length (days) | 45 (35;175) | 36 (32;60) | 0.03 | 47 (35;82) | 34 (28;37) | 0.03 | 0.92 |
| FG score | 6 (0;17) | 8 (3;12) | 0.79 | 6 (2;12) | 6 (2;12) | 0.40 | 0.49 |
| SHBG (nmol/L) | 30 (18;46) | 30 (14;37) | 0.78 | 35 (27;57) | 38 (29;44) | 0.88 | 0.92 |
| Free testosterone (nmol/L) | 0.032 (0.025;0.038) | 0.028 (0.025;0.045) | 0.89 | 0.027 (0.019;0.035) | 0.021 (0.017;0.028) | 0.06 | 0.70 |
| Total testosterone (nmol/L) | 1.5 (1.1;1.7) | 1.2 (1.0;1.8) | 0.39 | 1.5 (1.3;1.8) | 1.2 (0.9;1.7) | 0.10 | 0.28 |
| AMH (pmol/L) | 37.7 (25.1;51.8) | 36.0 (31.6;44.4) | 0.96 | 38.9 (33.9;78.4) | 38.3 (25.8;57.0) | 0.46 | 0.74 |
| FSH (IU/L) | 5.8 (4.6;7.0) | 5.4 (4.9;7.0) | 0.67 | 5.4 (3.3;6.0) | 5.7 (4.3;6.6) | 0.26 | 0.26 |
| LH (IU/L) | 8.9 (6.2;11.8) | 12.0 (9.4;16.0) | 0.15 | 12.5 (8.2;16.0) | 10.4 (5.0;13.5) | 0.16 | 0.04 |
| Estradiol (nmol/L) | 0.19 (0.14;0.41) | 0.18 (0.15;0.25) | 0.16 | 0.26 (0.17;0.70) | 0.19 (0.13;0.29) | 0.08 | 0.34 |
Values are shown as medians (IQR, interquartile range, 25%; 75%) BMI: body mass index, HOMA-IR: homeostatic model assessment for insulin resistance, HbA1c: hemoglobin A1c, HDL: high-density lipoprotein, LDL: low-density lipoprotein, FG: Ferriman–Gallwey, AMH: Anti-Müllerian hormone, FSH: follicle stimulating hormone, LH: luteinizing hormone, SHBG: sex hormone binding globulin. Δ p: p-value for Δ value (6–0 months), Δ vs. Δ p: p-value for comparison of the Δ values.