Figure 1.

Preparation method for gelatin hydrogels incorporating CDDP for sustained CDDP release. (A) Two-step method reported previously. First, gelatin is crosslinked by chemical crosslinking using glutaraldehyde or dehydrothermal crosslinking, and then the CDDP is incorporated into it. (B) The newly developed one-step method. By crosslinking gelatin with CDDP, gelatin crosslinking and CDDP incorporation are performed simultaneously. The binding mechanism between CDDP and gelatin molecules can be a coordinate bond between platinum atoms and the carboxyl groups of gelatin side chains.